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Research Projects

It is now well appreciated that adipocytes are not simply fat storage cells, but can be subdivided into white, brown and ‘beige’ cells, with the...

We have discovered that the initiation of a TCR signal in Treg cells entails docking of the Treg TCR in the opposite orientation to that observed for...
Supervisor: Dr Hugh Reid

Mass spectrometry is one of the leading technologies to comprehensively identify and quantify proteins and other biomolecules in virtually every...
Supervisor: Dr Ralf Schittenhelm

Natural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK cells and other...

The PI3K-Akt-mTOR signalling network plays a pivotal role in the regulation of cell growth and proliferation, and is highly complex with multiple...
Supervisor: Dr Lan Nguyen

Sense of touch (somato-sensation) becomes available to embryos even before birth and is one of the oldest senses in the animal kingdom, yet little is...
Supervisor: Dr Mehdi Adibi

Background: The Drimolen fossil site in South Africa has recently garnered international scientific attention and global news announcing the oldest...
Supervisor: Dr Jason Massey

We have identified specific insulins that act in the brain to control animal behaviour. This exciting project will use genetics, CRISPR, behavioural...

The mammalian oocyte is the largest cell in the body and undergoes two highly specialised asymmetric meiotic cell divisions. Coordination of...

The aim of this multidisciplinary project is to design techniques and build low-cost, efficient automated solutions for behavioural study in rodents...
Supervisor: Dr Mehdi Adibi

Neuroscience is becoming an exciting and multidisciplinary field, with a combination of biology, psychology, engineering, and large-data processing....
Supervisor: Dr Tatsuo Sato

Stem cell therapy holds immense potential as a treatment paradigm for a number of conditions. However, currently the therapeutic outcome is often...
Supervisor: Dr Mark Del Borgo

During the last decades, substantial advances have been made in the various ‘omics techniques’ (such as transcriptomics, proteomics, metabolomics and...
Supervisor: Dr Ralf Schittenhelm

Cryo-electron tomography (CET) allows for the highest resolution cellular imaging possible at the moment. To get access to all areas of the cell we...
Supervisor: Dr Georg Ramm

Pasteurella multocida is a Gram-negative bacterial pathogen that causes a number of different diseases in cattle, pigs and poultry, resulting in...

Antibiotic-resistance is a major problem in hospitals and different community settings. Dendritic cells are sentinel cells of the innate immune...

Anorexia nervosa (AN) has clear biological underpinnings, however, the molecular mechanisms that lead to the development of this debilitating...
Supervisor: Dr Claire Foldi

This project aims to design, synthesize and evaluate a novel class of oligonucleotides. Oligonucleotides have emerged as a revolutionary tool in...
Supervisor: Dr Nitin Patil

Non-ribosomal peptide synthesis is a complex biosynthetic process that produces many medically important peptide natural products, including several...

The malaria parasite Plasmodium falciparum employs metallo-aminopeptidase enzymes (PfMAP) that are required for parasite survival. Three of these...
Supervisor: Dr Sheena McGowan

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