Characterisation of the machinery involved in mammalian mitochondrial dynamics

This project will investigate the machinery involved in mitochondrial fission and fusion and the relationship between mitochondrial dynamics and cellular health. Defects in mitochondrial dynamics can result in neurological and muscular disease, optic atrophy and epilepsy. Projects involve the functional characterisation of proteins involved in mitochondrial dynamics using cell biology, microscopy, CRISPR/Cas9 gene editing and proteomic approaches. Integration of cell based approaches with animal studies is envisioned. Collaborations with international links will be fostered with potential to undertake a short research visit overseas. Projects will generate exciting new insights in this highly competitive field leading to high-impact publications. Strong mentorship within a fantastic, collaborative team is offered. See www.ryanlab.org for further details.