Description
We have discovered that the initiation of a TCR signal in Treg cells entails docking of the Treg TCR in the opposite orientation to that observed for TCRs from T effector T cells. How this affects TCR signalling thresholds in Tregs with respect to a second signal via co-stimulatory molecules will be investigated using co-receptor blocking antibodies in T cell lines expressing a panel of Treg TCRs.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
type 1 diabetes, structural biology, Biochemistry & Molecular Biology
School
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Available options
PhD/Doctorate
Honours
Time commitment
Full-time
Physical location
Biomedicine Discovery Institute
Co-supervisors
Prof
Jamie Rossjohn