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Co-receptor dependence of TCR signalling in proinsulin reactive human regulatory T cells

Description 
We have discovered that the initiation of a TCR signal in Treg cells entails docking of the Treg TCR in the opposite orientation to that observed for TCRs from T effector T cells. How this affects TCR signalling thresholds in Tregs with respect to a second signal via co-stimulatory molecules will be investigated using co-receptor blocking antibodies in T cell lines expressing a panel of Treg TCRs.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
type 1 diabetes, structural biology, Biochemistry & Molecular Biology
Available options 
PhD/Doctorate
Honours
Time commitment 
Full-time
Physical location 
Biomedicine Discovery Institute
Co-supervisors 
Prof 
Jamie Rossjohn

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