It is now well-established that the cancer stroma, including cancer-associated fibroblasts, plays a major role in development and progression of this malignancy. However, the detailed mechanisms remain unclear. We have used mass spectrometry-based proteomics to characterize how the proteome and phosphoproteome of cancer-associated fibroblasts (CAFs) differs from normal prostate fibroblasts. This project will use a variety of techniques including antibody arrays, cell signalling and biological assays, and knockdown approaches, to further characterize intercellular communication between CAFs and cancer cells, with the potential to identify new therapeutic strategies.
Prostate Cancer, cell signalling, Department of Biochemistry & Molecular Biology
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Top-up scholarship funding available