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Research Projects

A high body mass index (a clinical measure of adiposity) at mid‐life is an acknowledged risk factor for Alzheimer’s dementia (AD). Potential...

Insulin‐regulated aminopeptidase, IRAP, is highly expressed in fat and skeletal muscle where is it found to accompany the insulin‐responsive glucose...

The identification of classical brown and beige adipocytes in white fat depots in adults humans has heralded a new era in adipose tissue biology with...
Supervisor: Dr Garron Dodd

Chronic infectious diseases have a devastating effect on global health. HIV and Plasmodium falciparum both cause chronic disease and have evaded...
Supervisor: Dr Kim Jacobson

RESEARCH PROJECT BACKGROUND: The endocrine system controls cell-cell communication and coordinates almost all our daily activities. Abnormalities in...

Vaccines exploit the ability of the immune system to provide heightened, tailored responses to pathogens if the host has been infected prior – this...
Supervisor: Dr Kim Jacobson

We wish to understand the detailed molecular events that underlie the recruitment and regulation of chromatin-modifying complexes by their co‐factor...

We are interested in delineating the molecular pathways that control immune cell function during infection and inflammation. Our group is focused on...
Supervisor: Professor Colby Zaph

Phosphorylation events on amino acids other than serine, threonine and tyrosine are believed to play an important role in cancer cell biology. We...
Supervisor: Dr Ralf Schittenhelm

Preliminary data from the Nguyen-Daly lab has identified Fibroblast growth factor receptors (FGFRs) as promising therapeutic targets for triple-...
Supervisor: Dr Lan Nguyen

Standard cytotoxic cancer therapy often causes the death of the oocytes in primordial follicles, predisposing women to infertility and premature...
Supervisor: Dr Karla Hutt

The gastric carcinogenic bacterium Helicobacter pylori has a unique ability to withstand high acidity of the stomach by buffering its periplasm at pH...

Exosomes are small vesicles (50-150 nm in size) secreted by most cell types and are involved in cell - cell communication and regulation of immune...
Supervisor: Professor Brian Cooke

The discovery of giant viruses, comparable in size and complexity to simple cellular organisms has pushed back the frontier of the virus world....

The Hippo/YAP signalling pathway is frequently dysregulated (~80%) in breast cancer. Yet, efforts aimed at targeting this pathway for therapeutic...
Supervisor: Dr Lan Nguyen

Anti-mullerian Hormone (AMH) or Mullerian Inhibiting Substance (MIS) is fundamentally known for its crucial activities in gonadal development during...
Supervisor: Dr Kelly Walton

The treatment of bacterial infections in humans and animals has largely relied on the use of antibiotics for over 70 years. One consequence of the...
Supervisor: Professor Dena Lyras

The control of stem cell division and differentiation is crucial to ensure correct development of an embryo and to maintain tissue homeostasis during...

This project ewill fucntionally analyse novel genes found to be expressed in embryonic chicken gonads. Methods include standard and cutting edge...

The human genome is dominated by non-protein encoding information. Indeed, the differences between humans and other animals cannot be accounted for...

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