Defining the impacts of cancer treatments on the uterus and subsequent pregnancy

It is well-known that cancer treatments damage eggs in the ovary to impair fertility. However, the impacts of different cancer treatments on the inner lining of the uterus (endometrium) remain poorly understood. This can have diverse implications for female infertility, miscarriage and pregnancy complications. This study aims to improve our understanding of how different classes of cancer therapy may impact the uterus and its' function. This project will employ novel animal models, as well as human samples. We use a variety of techniques, including flow cytometry, single cell RNA sequencing, qRT-PCR, Western blotting, immunofluorescence, in situ hybridisation, 3D confocal imaging and ELISA.