Deciphering the dynamic membrane lipid remodelling in Acinetobacter baumannii and the interaction with membrane-targeting peptides

This ARC funded project will decipher the mechanism(s) underpinning the rapid and extensive membrane remodelling in the Gram-negative bacteria Acinetobacter baumannii, focusing on their predominant biogenesis and remodelling pathways and the interactions with membrane-targeting antimicrobial peptides. Importantly, this project will be the first to address critical knowledge gaps through an integrative systems pharmacology, biophysical and computational approach and will generate critical mechanistic information to expedite the future design of antimicrobial agents that are effective against membrane-remodelled bacterial variants.