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Dendritic cell recognition of antibiotic-resistant strains of methicillin-resistant Staphylococcus aureus

Antibiotic-resistance is a major problem in hospitals and different community settings. Dendritic cells are sentinel cells of the innate immune system that play a major role in sensing pathogens and alerting the adaptive immune system of their presence. We have found that methicillin-resistant Staphylococcus aureus (MRSA) that has developed resistance to last line antibiotics is poorly recognised by dendritic cells. Thus the normal cytokine and interferon production and antigen presentation functions of dendritic cells are compromised during infections with antibiotic-resistant MRSA. This project aims to understand the mechanisms underlying sensing of MRSA by dendritic cells and how this is compromised when MRSA develops resistance to antibiotics.
Essential criteria: 
Minimum entry requirements can be found here:
antibiotic-resistance, dendritic cells, department of biochemistry, innate immunity, cytokines
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Available options 
Time commitment 
Top-up scholarship funding available 
Physical location 
15 Innovation Walk

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