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Delivery of mRNA for kidney disease treatment

The mRNA therapeutics have emerged as a high potent new class of drug, revolutionizing disease treatments, such as therapeutic vaccines, monoclonal antibodies, immunomodulatory drugs and cell therapies. The successful application of mRNA-based COVID-19 vaccine in 2021 has proved the feasibility and effectiveness of mRNA drugs. Therefore, utilizing mRNA to prompt the cells to create therapeutic proteins is an excellent avenue to pursue in the effort to restore people to health. One of the hurdles in mRNA therapy is to find an efficient delivery method for disease treatments. mRNA can be rapidly and easily degraded inside and outside the cells. Besides that, for many disease treatments, mRNA has to be delivered to a specific organ for the best treatment effects. Thus, the overall aim of this project is to fully exert mRNA’s therapeutic power by enhancing cellular uptake using lipid-based nanoparticles and delivering mRNA into the injured kidney.
Essential criteria: 
Minimum entry requirements can be found here:
mRNA, kidney injury, drug delivery
Biomedicine Discovery Institute (School of Biomedical Sciences) » Biochemistry and Molecular Biology
Available options 
Masters by research
Time commitment 
Physical location 
15 Innovation Walk

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