Research Projects
Like many developed countries, the population of Australia is ageing; with 13.8% of the population currently over the age of 65 and predictions this...
Supervisor: Professor Nicole La Gruta
DC monitor the environment for potential “danger signals” that signify pathogen invasion, including non-homeostatic cell death caused by viruses. We...
Supervisor: Assoc Professor Mireille Lahoud
The presentation of post-translationally modified (PTM) peptides by cell surface MHC molecules increases the diversity of targets for recognition by...
Supervisor: Dr Nathan Croft
Our mothers programed the first decisions of our lives by mRNA dumping: the regulated translation of this maternal transcriptome controls the first...
Supervisor: Prof Traude Beilharz
Monoclonal antibodies (mAbs) that block checkpoint inhibitory receptors including Programmed Death (PD)-1 act directly on T cells to overcome ‘...
Supervisor: Assoc Professor Meredith O'Keeffe
Small noncoding RNAs are increasingly recognised as important regulators of gene expression and genome integrity across all kingdoms of life. This is...
Supervisor: Dr Peter Boag
The tyrosine kinase Src was the first proto-oncogene to be identified, and it is now known that Src plays an important role in several human cancers...
Supervisor: Professor Roger Daly
We are performing in-depth characterization of the microenvironment of human tumours, and discovering new mechanisms used by these cells to influence...
Supervisor: Dr Anne Fletcher
Single cell technologies are being rapidly adopted and accordingly, there is a high demand for intuitive tools and software that help with the...
Supervisor: Professor Nicholas Huntington
Natural killer (NK) cells are effector lymphocytes of the innate immune system that are known for their ability to kill transformed and virus-...
Supervisor: Professor Nicholas Huntington
When mitochondria are unable to function properly, the proteome changes to re-establish homeostasis. In this project, we will investigate why some...
Supervisor: Dr Luke Formosa
Trauma and uncontrolled bleeding is a major cause of morbidity worldwide. We have developed and structurally characterized potent monoclonal...
Supervisor: Professor James Whisstock
The project will use live cell imaging, molecular cell biology and infection models to understand how Candida albicans evades innate immune...
Supervisor: Assoc Professor Ana Traven
Complex I of the mitochondrial respiratory chain is a huge machine containing 44 different subunits. Following up on recent studies, (Formosa et al...
Supervisor: Dr Luke Formosa
Non-ribosomal peptide synthesis is a complex biosynthetic process that produces many medically important peptide natural products, including several...
Supervisor: Assoc Professor Max Cryle
One of the major areas of interest in our laboratory is the importance of chemokines and their receptors in the regulation of immune responses and...
Supervisor: Dr Remy Robert
For decades the immune system and the nervous system were thought to be completely cut off from one another. This was thought to be the explanation...
Supervisor: Leon Smyth
Almost 40%-50% of melanoma patients do not respond or can develop resistance to current checkpoint inhibition immunotherapy. While antigen-based...
Supervisor: Chen Li
Dendritic cells (DCs) are sentinel immune cells endowed with the unique capacity to initiate antigen specific immunity and tolerance. Owning their...
Supervisor: MICHAEL CHOPIN, PHD