The tumour stromal microenvironment shapes leukocyte responses

We are performing in-depth characterization of the microenvironment of human tumours, and discovering new mechanisms used by these cells to influence immune responses. Stromal cell signatures correlate strongly with poor patient outcomes, and with a lack of response to immunotherapy. We want to know why. We have developed novel tools and we are using a range of cell biology and bioinformatics techniques in human culture systems and mouse models to explore this fascinating, clinically relevant phenomenon. Fibroblasts in particular can make up to 90% of the tumor mass, yet their influence is still an active topic of investigation.