Research Projects
The academic research program within this laboratory is focused on defining the key molecular interactions underlying receptor recognition events...
Supervisor: Professor Jamie Rossjohn
Many bacteria are motile. Chemotaxis, mediated by chemoreceptors, plays an important role in bacterial survival and virulence. In this project, we...
Supervisor: Assoc Professor Anna Roujeinikova
Gram-negative bacteria have caused substantial multi-drug resistance (MDR) in both clinical and community settings. Antimicrobial peptides (AMPs),...
Supervisor: Nanoantibiotics - SHEN LAB
Some intermediary metabolic enzymes are upregulated in the liver of mice and humans with type 2 diabetes. Here we will test whether and how these...
Supervisor: Dr Adam Rose
Tumours lose features of multicellularity, such as tissue differentiation and coordinated cell division, and start to resemble colonial unicellular...
Supervisor: Dr David Goode
Cancer follows an evolutionary process shaped by the environment of the tumour. Deciphering which genes and processes enable tumour cells to adapt to...
Supervisor: Dr David Goode
This project uses spatial proteomics and transcriptomics data to map locations of immune cells within the vicinity of paediatric and adult brain...
Supervisor: Dr David Goode
Antibiotic resistance continues to emerge and intensify. Antimicrobial peptides (AMPs) are a promising alternative to current antibiotics, but...
Supervisor: Professor Mibel Aguilar
Unlike other infections in which one single encounter with the pathogen is enough to induce long-lasting protection, immunity to malaria might take...
Supervisor: Prof Diana Hansen
Stroke and trauma are the leading causes of brain damage in Australia. Although many people survive the initial event, they are left with devastating...
Supervisor: Leon Smyth
Advances in single-cell and spatial transcriptomics are transforming the study of gene regulation and cellular function. Single-cell RNA sequencing...
Supervisor: Professor Wei Shi
Studies from lower order organisms such as flies and worms have shown that mild mitochondrial dysfunction invokes a stress response that promotes...
Supervisor: Dr Adam Rose
RESEARCH BACKGROUND
Parkinson’s disease (PD) is one of the most common of the neurodegenerative disorders, affecting 1-2% of the population...
Supervisor: Dr Michael Lazarou
TCR recognition of peptide + MHC class I complexes (pMHCI) is central to CD8+ T cell function. It is clear that the nature of the TCR-pMHCI...
Supervisor: Professor Nicole La Gruta
DC take up, process and present antigen (Ag) to T cells to initiate immune responses. There are multiple DC subsets that are tailored for different...
Supervisor: Assoc Professor Mireille Lahoud
Development of protein nanopores for long sequence genome reading
Supervisor: Assoc Professor Michelle Dunstone
A central feature of inflammatory diseases is the migration of white blood cells into the affected tissues. This is controlled by a group of proteins...
Supervisor: Assoc Professor Martin Stone
Despite enormous progress in research, cancer remains a devastating disease worldwide. Since generally not all patients will respond to a specific...
Supervisor: Dr Lan Nguyen
Tuberous sclerosis, or “tuberous sclerosis complex” (TSC), is a lifelong genetic disorder that affects millions of individuals. TSC is manifest in...
Supervisor: Dr Charles Bayly-Jones
Therapies that enhance the immune response to tumours have revolutionised the management of cancer. However, most tumours do not have a high...
Supervisor: Professor Tony Tiganis