Loss of features of multicellularity in cancer

Tumours lose features of multicellularity, such as tissue differentiation and coordinated cell division, and start to resemble colonial unicellular organisms. We apply network biology and evolutionary analysis to bulk and single-cell RNA-sequencing data to understand how gene regulatory networks that evolved to enforce multicellularity are disrupted and rewired in cancer. From this we aim to develop new biomarkers to predict which patients will have better or worse clinical outcomes. Basic proficiency in programming and/or statistical analysis desired. Flexible working arrangements permitted.