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Network-based machine learning to discover biomarkers for cancer therapies

Description 
Despite enormous progress in research, cancer remains a devastating disease worldwide. Since generally not all patients will respond to a specific therapy, a great challenge in cancer treatment is the ability to predict which patients would benefit (or not) to a therapy of choice. This helps improve treatment efficacy and minimise unnecessary sufferings by non-responders. There is thus a pressing need to identify robust biomarkers (i.e. genes/proteins) that can accurately predict the right patients for the right drugs. With the increasing availability of molecular and drug-response data, machine learning approaches provide a powerful tool for this task. This project will utilise key data science techniques including data processing, integration, analysis and visualisation; and then use these data to develop useful machine-learning frameworks to identify optimal biomarkers for different cancer types. A distinguishing feature of is that we will take advantage of network-based analyses of pharmacogenomics data in order to derive network-based features for the learners, which are expected to boost predictive accuracy. There are several sub-projects with different focus on specific methods to accommodate more than one students. Students will have a unique opportunity to work with real-life biomedical data and contribute towards solving a critical challenge in cancer research in Dr Lan Nguyen’s lab. They will be able to develop their skills in a highly interdisciplinary research group with expertise in both computational & biomedical fields. Experience in Python, R, or MATLAB (or an equivalent language) is essential. There are also potential opportunities to continue to PhD studies
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
machine learning, deep learning, data science, bioinformatics, computational biology, biomarker, cancer, cancer therapy
Available options 
PhD/Doctorate
Masters by research
Honours
Short projects
Joint PhD/Exchange Program
Time commitment 
Full-time
Part-time
Top-up scholarship funding available 
No
Physical location 
Clayton Campus

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