Research Projects
The thymus is primarily responsible for generating naïve, self-tolerant T cells from hematopoietic precursors. However, deterioration of thymic...
Supervisor: Assoc Professor Ann Chidgey
Single cell technologies are being rapidly adopted and accordingly, there is a high demand for intuitive tools and software that help with the...
Supervisor: Professor Nicholas Huntington
Natural killer (NK) cells are effector lymphocytes of the innate immune system that are known for their ability to kill transformed and virus-...
Supervisor: Professor Nicholas Huntington
When mitochondria are unable to function properly, the proteome changes to re-establish homeostasis. In this project, we will investigate why some...
Supervisor: Dr Luke Formosa
Iron is essential for bacterial growth, but it is severely limited in most environments. Bacteria have evolved clever systems to acquire this...
Supervisor: Dr Francesca Short
Trauma and uncontrolled bleeding is a major cause of morbidity worldwide. We have developed and structurally characterized potent monoclonal...
Supervisor: Professor James Whisstock
Pseudomonas aeruginosa is a Gram-negative bacterium that is one of the most common pathogens of people with cystic fibrosis. This organism causes...
Supervisor: Assoc Professor John Boyce
Pulmonary hypertension is a disease of high blood pressure in the lungs, which leads to increased right ventricular afterload, remodelling and...
Supervisor: Dr Kristen Bubb
The Mpox virus is endemic in West and Central African countries. In 2022, the WHO declared Mpox a global health emergency as infections have spread...
Supervisor: Dr Gabriela Khoury
The project will use live cell imaging, molecular cell biology and infection models to understand how Candida albicans evades innate immune...
Supervisor: Assoc Professor Ana Traven
Complex I of the mitochondrial respiratory chain is a huge machine containing 44 different subunits. Following up on recent studies, (Formosa et al...
Supervisor: Dr Luke Formosa
Mitochondria more than just “the powerhouse of the cell”. They are fascinating, highly dynamic organelles that carry out an array of cellular...
Supervisor: Dr Kate McArthur
Cellular aging is a complex biological process involving a gradual decline in cellular function and increased vulnerability to disease. It is...
Supervisor: Dr Iman Azimi
Non-ribosomal peptide synthesis is a complex biosynthetic process that produces many medically important peptide natural products, including several...
Supervisor: Assoc Professor Max Cryle
FIKK kinases are unique among apicomplexan parasites. Interestingly the genome of P. falciparum encodes 20 FIKK kinases, but very little is known...
Supervisor: Professor Brian Cooke
Clostridium difficile is recognised as the major cause of nosocomial diarrhoea in Australian hospitals and in hospitals worldwide. Chronic colitis...
Supervisor: Professor Dena Lyras
The spleen is an important organ of the immune system and it is often removed for the treatment of different medical conditions, to perform surgery...
Supervisor: Dr Gabriela Khoury
Background:
Polycystic kidney disease (PKD) is the most common potentially lethal Mendelian disease, affecting around 1/1000 people. It arises when...
Supervisor: Assoc Professor Ian Smyth
Antibiotics are a precious and diminishing resource. There is a desperate need to reduce or replace the use of antibiotics to treat bacterial...
Supervisor: Professor Dena Lyras
One of the major areas of interest in our laboratory is the importance of chemokines and their receptors in the regulation of immune responses and...
Supervisor: Dr Remy Robert