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Research Projects

It is well-established that neurons in the whisker area of somatosensory cortex and thalamus exhibit directional selectivity. Direction preference is...
Supervisor: Dr Mehdi Adibi

Our mothers programed the first decisions of our lives by mRNA dumping: the regulated translation of this maternal transcriptome controls the first...

Monoclonal antibodies (mAbs) that block checkpoint inhibitory receptors including Programmed Death (PD)-1 act directly on T cells to overcome ‘...

Recently, novel genetic variants of GPR75 were discovered to be associated with leanness in large genome wide associated studies. This is the first...

All living things respond to changes in their direct environment by evoking innate stress response mechanisms. Multiple factors, including those...
Supervisor: Dr Kylie Wagstaff

Chronic kidney disease CKD is an inflammatory condition that is increasing in prevalence around the world. Diabetes and obesity are the primary cause...

This study investigates the role of Smad3 acetylation in the development and progression of organ/tissue fibrosis.

Small noncoding RNAs are increasingly recognised as important regulators of gene expression and genome integrity across all kingdoms of life. This is...
Supervisor: Dr Peter Boag

The tyrosine kinase Src was the first proto-oncogene to be identified, and it is now known that Src plays an important role in several human cancers...
Supervisor: Professor Roger Daly

Dysfunctional feeding behaviour encompasses energy overconsumption (obesity, binge eating) to malnutrition (unhealthy food choices, excessive dieting...

Heme is an essential nutrient for the bacterial pathogen Haemophilus influenzae, which causes serious respiratory infections, otitis media and...
Supervisor: Dr Rhys Grinter

We are performing in-depth characterization of the microenvironment of human tumours, and discovering new mechanisms used by these cells to influence...
Supervisor: Dr Anne Fletcher

Development of therapeutic antibodies to treat human diseases

The oocyte-secreted TGF-beta proteins, BMP15 and GDF9, are essential for the acquisition of oocyte developmental competence during folliculogenesis....

The oocyte-secreted factors, bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), are essential for the acquisition of...
Supervisor: Dr Kelly Walton

The thymus is primarily responsible for generating naïve, self-tolerant T cells from hematopoietic precursors. However, deterioration of thymic...

Single cell technologies are being rapidly adopted and accordingly, there is a high demand for intuitive tools and software that help with the...

The adaptive arm of immune system uses lymphocytes to generate antibody and memory responses to challenges throughout life. Three lineages of...
Supervisor: Dr Martin Davey

Natural killer (NK) cells are effector lymphocytes of the innate immune system that are known for their ability to kill transformed and virus-...

When mitochondria are unable to function properly, the proteome changes to re-establish homeostasis. In this project, we will investigate why some...
Supervisor: Dr Luke Formosa

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