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Research Projects

Pleurotolysin: a pore forming toxin from the carnivorous oyster mushroom

The PI3K-Akt-mTOR signalling network plays a pivotal role in the regulation of cell growth and proliferation, and is highly complex with multiple...
Supervisor: Dr Lan Nguyen

Excess body weight is a major and leading factor in overall disease burden worldwide and if left unabated could lead to falls in overall life...

Protein-RNA interactions are integral to cellular biology – both in normal cellular function and also in cells subject to the stresses of viral...

Cancer therapy and oncology has entered a new exciting era of targeted therapy and personalised patient treatment, but resistance and tumour...
Supervisor: Dr Lan Nguyen

When someone develops acute kidney injury, clinical care is directed towards supporting them to allow their kidneys to repair. Sometimes this is not...
Supervisor: Professor Roger Evans

The laboratory is interested in the transcriptional and epigenetic mechanisms that govern cell identity, in particular pluripotency and the...

Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory...

The mammalian oocyte is the largest cell in the body and undergoes two highly specialised asymmetric meiotic cell divisions. Coordination of...

The Bcl-2 family of proteins is crucial for apoptosis (a form of programmed cell death) regulation. The Bcl-2 proteins are synthesized in cytosolic...

Hypertension and its associated complications affect men and women during different stages of their lives. Our research is focusing on what controls...
Supervisor: Dr Katrina Colafella

Inflammation is the body’s response to injury or infection. A key feature of inflamed tissues is the accumulation of leukocytes (white blood cells),...

The Combes laboratory has opportunities for postgraduate research projects in the fields of bioinformatics/single cell genomics, developmental...
Supervisor: Dr Alex Combes

The prevalence of diabetes mellitus continues to increase worldwide leading to premature mortality. About 30% of patients with type 2 diabetes (T2D)...

Eukaryotic transcriptional co-activators are multi-subunit complexes that both modify chromatin and recognize histone modifications to control gene...
Supervisor: Dr Dominika Elmlund

The majority of cancer deaths are attributed to metastases rather than the primary tumour. Therefore, the development of new therapeutics targeting...
Supervisor: Dr Andrew Ellisdon

The immune system comprises a variety of effector cells that are uniquely poised to recognize infected or transformed cells. However, the capacity of...
Supervisor: Dr Richard Berry

The majority of cancer deaths are attributed to metastases rather than the primary tumour. Therefore, the development of new therapeutics targeting...
Supervisor: Dr Andrew Ellisdon

Viruses and pathogens are part of day-to-day encounters that the immune system needs to deal with. How the immune system “sees”, recognises and...

SAGA’s many functions are essential for normal embryo development in flies and mice. Mutation or altered expression of SAGA subunits are associated...
Supervisor: Dr Hans Elmlund

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