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Research Projects

Cancer cachexia is the progressive loss of body weight, accompanied by loss of appetite, which affects around 80% of cancer patients. Inappropriate...
Supervisor: Dr Sarah Lockie

Damage to primary visual cortex will cause cortical blindness, a condition where patients no longer have conscious visual perception in the parts of...
Supervisor: Dr Leo Lui

The laboratory is interested in the transcriptional and epigenetic mechanisms that govern cell identity, in particular pluripotency and the...

The cochlea is the organ of the inner ear essential for hearing. It is embedded in the skull and converts sound waves into electrical impulses...

We are facing an era where the antibiotic cornerstone of modern medicine is under threat due to bacterial resistance. Deadly superbugs are not only...
Supervisor: Dr Jennifer Payne

Background: Mitochondria are energy-producing organelles. They form a network inside cells, and their health is critical to cell function....
Supervisor: Dr Georg Ramm

Natural killer (NK) cells are innate lymphocytes that play a vital role in the immune response through their ability to directly kill transformed and...

The immune system is one of the most dynamic in our bodies. The mechanisms that maintain immune homeostasis must contend with the constant churn of...

Our laboratory has a major interest in breast cancer, particularly the triple negative/basal breast cancer subtype, which is associated with poor...
Supervisor: Professor Roger Daly

Two key pathways controlling amino acid homeostasis are the cellular sensors mTOR and GCN2 but these cannot be the only ones. Here using cell based...
Supervisor: Dr Adam Rose

One of the most recognised risk factors for cardiovascular disease is hypertension. Cardiac fibrosis is at the centre of many pathological conditions...

Background Nuclear transport is central to eukaryotic cell processes such as signal transduction and differentiation, where changes in transcription...
Supervisor: Professor David Jans

Nuclear transport inhibitors to combat diseases Two major health burdens world-wide are cancer and infectious diseases like viral illnesses and...
Supervisor: Professor David Jans

Hepatocellular carcinoma (HCC) is one of the most fatal and fastest growing cancers. In recent years, non-alcoholic steatohepatitis (NASH) has been...
Supervisor: Professor Colby Zaph

The Prostate Cancer Research Group is a group of scientists and clinical fellows working together to study male urological biology and disease....

This project aims to engineer new biomaterials that can permanently integrate with the brain. This project expects to generate new knowledge using...

Every ageing woman faces potentially debilitating physical symptoms following the cessation of ovarian function at menopause. Crucially, many of...
Supervisor: Dr Kelly Walton

Gonadal-derived inhibin A and inhibin B are essential factors in mammalian reproduction, negatively regulating pituitary production of follicle...

This project aims to determine how antibiotic resistance and toxin plasmids are replicated and maintained in this important bacterial pathogen
Supervisor: Professor Julian Rood

Pleurotolysin: a pore forming toxin from the carnivorous oyster mushroom

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