The mammalian oocyte is the largest cell in the body and undergoes two highly specialised asymmetric meiotic cell divisions. Coordination of organelle inheritance, polarity and meiotic progression is essential for the production of an oocyte capable of undergoing fertilization and development to term. We use molecular and genetic approaches combined with live cell imaging to investigate the cell biology of these processes in mice and humans. Investigating these questions allows us to understand how oocytes make the transition into a healthy embryo and why it goes wrong in cases such as maternal ageing.
Oocyte, Meiosis, Fertility Development, Reproduction Ageing, Mitochondria
Biomedicine Discovery Institute (School of Biomedical Sciences) » Anatomy and Developmental Biology
Masters by research
Top-up scholarship funding available
Biomedicine Discovery Institute