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Research Projects

The majority of cancer deaths are attributed to metastases rather than the primary tumour. Therefore, the development of new therapeutics targeting...
Supervisor: Dr Andrew Ellisdon

Viruses and pathogens are part of day-to-day encounters that the immune system needs to deal with. How the immune system “sees”, recognises and...

Perforin and the Complement Membrane Attack Complex (MAC) are related pore forming immune effectors that are deployed by the immune system to...

In this project, in collaboration with Professor Ross Hannan (ANU), we will study the structure of Upstream Binding Factor (UBF) in complex with...

SAGA’s many functions are essential for normal embryo development in flies and mice. Mutation or altered expression of SAGA subunits are associated...
Supervisor: Dr Hans Elmlund

Like many developed countries, the population of Australia is ageing; with 13.8% of the population currently over the age of 65 and predictions this...

Post-translational modification of joint proteins leads to the generation of autoantigenic peptides that drive the inflammatory response in...
Supervisor: Dr Hugh Reid

Neurogenesis describes the fundamental process of generating neurons that integrate into existing circuits. Although originally thought to cease...

Cancer cachexia is a life-threatening condition characterised by a progressive loss of skeletal muscle and fat mass. Up to 80% of patients with...

Interleukin-1 (IL-1) family cytokines play key roles in the initiation and regulation of innate immunity and inflammation. As such, it is...
Supervisor: Dr Andrew Ellisdon

This study is focused on understanding the of the role of gut microbial metabolites on the mitochondria function and how may affect immune-metabolic...

This project aims to develop new antisense oligonucleotides as an efficient and common therapeutic for targeting the polymyxin resistant gram-...
Supervisor: Dr Nitin Patil

Hypertension is a major cause of heart failure, heart attacks and strokes. Associated with the development of hypertension is the accumulation of...

Pulmonary hypertension (PH) is an incurable disease and a major cause of death and illness throughout the world. Whilst there has been advancement...

Background: Strong climatic changes may have been the primary drivers of human evolution. Understanding how early human (hominin) foraging and...
Supervisor: A/Prof Luca Fiorenza

In celiac disease (CD), the T cell response to gliadin peptides derived from gluten in from wheat, barley and rye has been well characterised....
Supervisor: Dr Hugh Reid

Bariatric surgery has now been accepted as a front-line treatment for type 2 diabetes (T2D) that compares favourably with lifestyle and medicinal...
Supervisor: Dr Aneta Stefanidis

Bariatric surgery has now been accepted as a front-line treatment for type 2 diabetes (T2D) that compares favourably with lifestyle and medicinal...

Viruses and humans have coevolved for millions of years and during this time viruses have armed themselves with strategies to hijack or evade our...
Supervisor: Dr Natalie Borg

DC monitor the environment for potential “danger signals” that signify pathogen invasion, including non-homeostatic cell death caused by viruses. We...

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