Research Projects
The laboratory is interested in the transcriptional and epigenetic mechanisms that govern cell identity, in particular pluripotency and the...
Supervisor: Assoc Professor Jose Polo
Here we will combine omics technologies with novel muscle-specific gene manipulation technologies to discover novel signalling pathways controlling...
Supervisor: Dr Adam Rose
Plasmin (Plm) plays a crucial role in blood clot dissolution (fibrinolysis), inflammation, cellular migration and wound healing. Alpha2-antiplasmin (...
Supervisor: Dr Ruby Law
Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory...
Supervisor: Professor Nicholas Huntington
The mammalian oocyte is the largest cell in the body and undergoes two highly specialised asymmetric meiotic cell divisions. Coordination of...
Supervisor: Professor John Carroll
The Bcl-2 family of proteins is crucial for apoptosis (a form of programmed cell death) regulation. The Bcl-2 proteins are synthesized in cytosolic...
Supervisor: Professor Mibel Aguilar
Hypertension and its associated complications affect men and women during different stages of their lives. Our research is focusing on what controls...
Supervisor: Dr Katrina Colafella
Inflammation is the body’s response to injury or infection. A key feature of inflamed tissues is the accumulation of leukocytes (white blood cells),...
Supervisor: Assoc Professor Martin Stone
Mountain gorillas currently live in two, discontinuous localities in east and central Africa: the Virunga Mountains and Bwindi Impenetrable Forest....
Supervisor: Dr Jason Massey
Alternative splicing is a regulatory pathway that can can change the messenger RNA produced from a gene and subsequently the proteins that are...
Supervisor: Dr Carlos Rosado
Spatiotemporal dynamics of cortical network activity: the link between micro- and mesoscale activity
Spontaneous synchronization is a common phenomenon occurring in diverse contexts, from a group of glowing fireflies or chirping crickets in a field...
Supervisor: Dr Mehdi Adibi
We have identified specific sphingolipids that control brain development and protect the nervous system throughout life. This exciting project will...
Supervisor: Professor Roger Pocock
The Combes laboratory has opportunities for postgraduate research projects in animal and stem cell models of kidney development and disease, advanced...
Supervisor: Dr Alex Combes
The prevalence of diabetes mellitus continues to increase worldwide leading to premature mortality. About 30% of patients with type 2 diabetes (T2D)...
Supervisor: Professor Sharon Ricardo
This project examines how weight gain is affected by stress and the bidirectional relationship between mind and body in stress, metabolism, comfort...
Supervisor: Dr Kevin Lee
Eukaryotic transcriptional co-activators are multi-subunit complexes that both modify chromatin and recognize histone modifications to control gene...
Supervisor: Dr Dominika Elmlund
The immune system comprises a variety of effector cells that are uniquely poised to recognize infected or transformed cells. However, the capacity of...
Supervisor: Dr Richard Berry
The majority of cancer deaths are attributed to metastases rather than the primary tumour. Therefore, the development of new therapeutics targeting...
Supervisor: Associate Professor Andrew Ellisdon
Viruses and pathogens are part of day-to-day encounters that the immune system needs to deal with. How the immune system “sees”, recognises and...
Supervisor: Assoc Professor Stephanie Gras
Perforin and the Complement Membrane Attack Complex (MAC) are related pore forming immune effectors that are deployed by the immune system to...
Supervisor: Professor James Whisstock