Research Projects
The majority of cancer deaths are attributed to metastases rather than the primary tumour. Therefore, the development of new therapeutics targeting...
Supervisor: Dr Andrew Ellisdon
Viruses and pathogens are part of day-to-day encounters that the immune system needs to deal with. How the immune system “sees”, recognises and...
Supervisor: Assoc Professor Stephanie Gras
Perforin and the Complement Membrane Attack Complex (MAC) are related pore forming immune effectors that are deployed by the immune system to...
Supervisor: Professor James Whisstock
In this project, in collaboration with Professor Ross Hannan (ANU), we will study the structure of Upstream Binding Factor (UBF) in complex with...
Supervisor: Professor James Whisstock
SAGA’s many functions are essential for normal embryo development in flies and mice. Mutation or altered expression of SAGA subunits are associated...
Supervisor: Dr Hans Elmlund
Like many developed countries, the population of Australia is ageing; with 13.8% of the population currently over the age of 65 and predictions this...
Supervisor: Professor Nicole La Gruta
Post-translational modification of joint proteins leads to the generation of autoantigenic peptides that drive the inflammatory response in...
Supervisor: Dr Hugh Reid
Neurogenesis describes the fundamental process of generating neurons that integrate into existing circuits. Although originally thought to cease...
Supervisor: Professor Zhi-Cheng Xiao
Cancer cachexia is a life-threatening condition characterised by a progressive loss of skeletal muscle and fat mass. Up to 80% of patients with...
Supervisor: Assoc Professor Craig Harrison
Interleukin-1 (IL-1) family cytokines play key roles in the initiation and regulation of innate immunity and inflammation. As such, it is...
Supervisor: Dr Andrew Ellisdon
This study is focused on understanding the of the role of gut microbial metabolites on the mitochondria function and how may affect immune-metabolic...
Supervisor: Dr Eliana Marino Moreno
This project aims to develop new antisense oligonucleotides as an efficient and common therapeutic for targeting the polymyxin resistant gram-...
Supervisor: Dr Nitin Patil
Hypertension is a major cause of heart failure, heart attacks and strokes. Associated with the development of hypertension is the accumulation of...
Supervisor: Dr Barbara Kemp-Harper
Pulmonary hypertension (PH) is an incurable disease and a major cause of death and illness throughout the world. Whilst there has been advancement...
Supervisor: Dr Barbara Kemp-Harper
Background:
Strong climatic changes may have been the primary drivers of human evolution. Understanding how early human (hominin) foraging and...
Supervisor: A/Prof Luca Fiorenza
In celiac disease (CD), the T cell response to gliadin peptides derived from gluten in from wheat, barley and rye has been well characterised....
Supervisor: Dr Hugh Reid
Bariatric surgery has now been accepted as a front-line treatment for type 2 diabetes (T2D) that compares favourably with lifestyle and medicinal...
Supervisor: Dr Aneta Stefanidis
Bariatric surgery has now been accepted as a front-line treatment for type 2 diabetes (T2D) that compares favourably with lifestyle and medicinal...
Supervisor: Professor Brian Oldfield
Viruses and humans have coevolved for millions of years and during this time viruses have armed themselves with strategies to hijack or evade our...
Supervisor: Dr Natalie Borg
DC monitor the environment for potential “danger signals” that signify pathogen invasion, including non-homeostatic cell death caused by viruses. We...
Supervisor: Assoc Professor Mireille Lahoud