Research Projects
We develop methods for single particle electron microscopy (SPEM). Our SPEM developments are motivated by our interest in transcriptional control...
Supervisor: Dr Dominika Elmlund
Our vision: "driving excellence in medical research to build a healthier future"
Our research centres on an exciting development in...
Supervisor: Dr Eliana Marino Moreno
Studies from lower order organisms such as flies and worms have shown that mild mitochondrial dysfunction invokes a stress response that promotes...
Supervisor: Dr Adam Rose
RESEARCH BACKGROUND
Parkinson’s disease (PD) is one of the most common of the neurodegenerative disorders, affecting 1-2% of the population...
Supervisor: Dr Michael Lazarou
TCR recognition of peptide + MHC class I complexes (pMHCI) is central to CD8+ T cell function. It is clear that the nature of the TCR-pMHCI...
Supervisor: Professor Nicole La Gruta
DC take up, process and present antigen (Ag) to T cells to initiate immune responses. There are multiple DC subsets that are tailored for different...
Supervisor: Assoc Professor Mireille Lahoud
Development of protein nanopores for long sequence genome reading
Supervisor: Assoc Professor Michelle Dunstone
A central feature of inflammatory diseases is the migration of white blood cells into the affected tissues. This is controlled by a group of proteins...
Supervisor: Assoc Professor Martin Stone
Despite enormous progress in research, cancer remains a devastating disease worldwide. Since generally not all patients will respond to a specific...
Supervisor: Dr Lan Nguyen
The cochlea is the organ of the inner ear essential for hearing. It is embedded in the skull and converts sound waves into electrical impulses...
Supervisor: Professor Phillip Bird
We are facing an era where the antibiotic cornerstone of modern medicine is under threat due to bacterial resistance. Deadly superbugs are not only...
Supervisor: Dr Jennifer Payne
Tuberous sclerosis, or “tuberous sclerosis complex” (TSC), is a lifelong genetic disorder that affects millions of individuals. TSC is manifest in...
Supervisor: Dr Charles Bayly-Jones
Therapies that enhance the immune response to tumours have revolutionised the management of cancer. However, most tumours do not have a high...
Supervisor: Professor Tony Tiganis
Background: Mitochondria are energy-producing organelles. They form a network inside cells, and their health is critical to cell function....
Supervisor: Dr Georg Ramm
The immune system is one of the most dynamic in our bodies. The mechanisms that maintain immune homeostasis must contend with the constant churn of...
Supervisor: Professor Nicholas Huntington
Metabolite based T cell immunity is emerging as a major player in antimicrobial immunity, autoimmunity, cancer, and metabolic diseases. Initially,...
Supervisor: Dr Wael Awad
Our laboratory has a major interest in breast cancer, particularly the triple negative/basal breast cancer subtype, which is associated with poor...
Supervisor: Professor Roger Daly
Two key pathways controlling amino acid homeostasis are the cellular sensors mTOR and GCN2 but these cannot be the only ones. Here using cell based...
Supervisor: Dr Adam Rose
One of the most recognised risk factors for cardiovascular disease is hypertension. Cardiac fibrosis is at the centre of many pathological conditions...
Supervisor: Professor Mibel Aguilar
Background
Nuclear transport is central to eukaryotic cell processes such as signal transduction and differentiation, where changes in transcription...
Supervisor: Professor David Jans