Research Projects
The gastric carcinogenic bacterium Helicobacter pylori has a unique ability to withstand high acidity of the stomach by buffering its periplasm at pH...
Supervisor: Assoc Professor Anna Roujeinikova
In several cancer types, a higher tumour mutational burden (TMB) has been associated with increased immune cell infiltration into tumours and better...
Supervisor: Professor Nicholas Huntington
The discovery of giant viruses, comparable in size and complexity to simple cellular organisms has pushed back the frontier of the virus world....
Supervisor: Assoc Professor Fasseli Coulibaly
The Hippo/YAP signalling pathway is frequently dysregulated (~80%) in breast cancer. Yet, efforts aimed at targeting this pathway for therapeutic...
Supervisor: Dr Lan Nguyen
The human genome is dominated by non-protein encoding information. Indeed, the differences between humans and other animals cannot be accounted for...
Supervisor: Prof Traude Beilharz
Small cell lung cancer (SCLC) is an incredibly aggressive form of lung cancer with limited treatment options, begging the need for major
therapeutic...
Supervisor: Professor Nicholas Huntington
The MACPF/CDC family proteins use a common fold to oligomerise into a ring-shaped transmembrane pore capable of either direct cell lysis or passive...
Supervisor: Assoc Professor Michelle Dunstone
Gastric cancer is a leading cause of cancer-related death, claiming more than 1 million lives annually. A major predisposing factor to developing...
Supervisor: Dr Dustin Flanagan
Developing tumour cells interact with a complex and heterogeneous ecosystem, namely the tumour microenvironment (TME), comprising mutant and wild-...
Supervisor: Dr Dustin Flanagan
Cancer cells can acquire stromal or developmental-like phenotypes allowing them to masquerade as other cell types, making the challenge of...
Supervisor: Dr Dustin Flanagan
Cancer develops through a complex evolutionary process where cells acquire mutations that accelerate their growth, compete and co-operate with each...
Supervisor: Dr David Goode
The food intake of the mother during gestation and the breastfeeding period has far-reaching consequences for the development of the child and their...
Supervisor: Dr. Asolina Braun
People with underlying non-communicable disease have lower tolerance and worse outcomes to infections but we don't understand why. To begin to...
Supervisor: Dr Adam Rose
This project is part of the RNA Systems Biology Lab's ambition to de-risk discovery and translational research using a novel RNA-seq based...
Supervisor: Prof Traude Beilharz
Mitochondria are key players in health and disease. They are the main source of energy in eukaryotic cells, oxidizing sugars and fats to generate ATP...
Supervisor: Professor Mike Ryan
The academic research program within this laboratory is focused on defining the key molecular interactions underlying receptor recognition events...
Supervisor: Professor Jamie Rossjohn
Background:
The innate immune system senses and responds to endogenous and exogenous danger signals in order to protect the host. cGAMP synthase (...
Supervisor: Dr Dominic De Nardo
The academic research program within this laboratory is focused on defining the key molecular interactions underlying receptor recognition events...
Supervisor: Professor Jamie Rossjohn
This project will explore the human T cell receptor molecular recognition of mycobacterial lipid antigens presented by CD1b. These lipids are unique...
Supervisor: Dr Adam Shahine
To survive in an environment regularly exposed to fungal, bacterial, parasitic, and viral pathogens, the adaptive arm of the immune system of jawed...
Supervisor: A/Prof Jerome Le Nours