Research Projects
Brain inflammation appears to play a critical role in the pathogenesis of epilepsy. A major cell type involved in inflammatory cascades are the...
Supervisor: Assoc Professor Nigel Jones
Oesophageal function is complex and various methods have been developed to assess this. Oesophageal manometry, which involves synchronous recording...
Supervisor: Dr Paul Burton
The development of diabetic complications including vascular and renal disease is enhanced in diabetic patients. However, the underlying mechanism as...
Supervisor: Dr Jay C. Jha
Project overview: Plasminogen activation plays a key role in fibrinolysis, which is the process of blood clot removal. Plasminogen is an inactive...
Supervisor: Professor Robert Medcalf
This project seeks to further improve the behavior of our prototype peptide inhibitor CHA-061 against the profibrotic effect of CDA1. CHA-061 is a...
Supervisor: Dr Zhong-Lin Chai
Despite an increase in the number of women with severe mental illness desiring families and a subsequent increase in the rate of antenatal...
Supervisor: Professor Jayashri Kulkarni
Most neurological disorders, e.g. Alzheimer's, Parkinson's Disease, etc.. are associated with the build up of toxic proteins, which can...
Supervisor: Dr Ben Sinclair
There is accumulating evidence that diet can play a key role in improving depressive symptoms. The most compelling evidence so far is for traditional...
Supervisor: Assoc Prof Heidi Staudacher
Characterising donor specific B cells and how this relates to transplantation outcomes.
Supervisor: Prasanti Kotagiri
There is no defined optimal treatment for functional cognitive disorders (FCD), despite effective treatments being desperately needed. This research...
Supervisor: Dr Lana Higson
Epilepsy is one of the most common serious chronic neurological disorders and is estimated to affect approximately 68 million people worldwide....
Supervisor: Professor Patrick Kwan
Nucleotide synthesis enzymes (NSEs), including IMPDH2, GMPS, and CTPS1, are traditionally
characterised as cytoplasmic proteins that support tumour...
Supervisor: Dr Gamze Kuser Abali
The bladder is a unique and often forgotten mucosal site. When the bladder is exposed to bacterial pathogens it sheds superficial epithelial cells to...
Supervisor: Dr Malcolm Starkey
Bronchopulmonary dysplasia (BPD) is a severe lung disease that is the main cause of disability and death in premature infants. Recent studies suggest...
Supervisor: Assoc Professor Margaret Hibbs
Inborn Errors of Immunity (IEIs) are caused by rare genetic variants, yet many patients especially those with Predominantly Antibody Deficiency (PAD...
Supervisor: Dr Emily Edwards
Cancer is a heterogeneous disease, with differences not only among different patients, but even amongst the bulk of cells within tumors in individual...
Supervisor: Dr Mark Shackleton
The Mpox virus is endemic in West and Central African countries. In 2022, the WHO declared Mpox a global health emergency as infections have spread...
Supervisor: Dr Gabriela Khoury
Based at the Central Clinical School, our laboratory works closely with clinicians at the Alfred Hospital to study mechanisms of cancer development...
Supervisor: Dr Gamze Kuser Abali
Paediatric chronic pain is defined by the International Association for the Study of Pain as persistent or recurring pain that lasts for longer than...
Supervisor: Professor Richelle Mychasiuk
The spleen is an important organ of the immune system and it is often removed for the treatment of different medical conditions, to perform surgery...
Supervisor: Dr Gabriela Khoury