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Research Projects

Clinical utility and cost-effectiveness of genomic sequencing for epilepsy
Genetic variants have been found to cause epilepsy as well as affect how people respond to treatment. Whole exome sequencing is a new method of...
Supervisor: Professor Patrick Kwan
Curating structural variants in epilepsy
The application of whole genome sequencing (WGS) in the clinical care of patients with epilepsy is increasingly viable as the cost of these assays...
Supervisor: Professor Patrick Kwan
Developing a new class of medications for epilepsy
Failure of modern ASMs to reduce the prevalence of drug-resistant epilepsy has been attributed to over-reliance on rodent models of acute seizures in...
Supervisor: Professor Patrick Kwan
Development of a low cost, point-of-care diagnostic platform
Point-of-care (POC) testing is the testing at the site of patient care. It is done on patients conveniently and immediately allowing patients and...
Supervisor: Professor Patrick Kwan
Long-term Prognosis of Antiepilpetic Drug Therapy in People with Newly Diagnosed and Treated Epilepsy
Antiepileptic drug is the mainstay of treatment modality for epilepsy. People with epilepsy often require lifelong antiepileptic drug treatment....
Supervisor: Professor Patrick Kwan
Machine learning models for personalised epilepsy management
The current standard of care for epilepsy is to commence treatment with a single antiseizure medication (ASM) and if it fails, try successive drug...
Supervisor: Professor Patrick Kwan
Management and prognosis of first seizure and newly diagnosed epilepsy
Seventy million people have epilepsy with 34–76 per 100,000 developing the condition every year. To formulate rational treatment plans, it is...
Supervisor: Professor Patrick Kwan
Management of seizures and epilepsy in residential aged care facilities in Australia
Older age is now the most common time to develop epilepsy in high income settings. This is thought to be due to age related neurobiological changes...
Supervisor: Professor Patrick Kwan
Predictors and mechanisms of cutaneous adverse drug reactions: a multi-omic approach
Mainstream anti-epileptic drugs (AEDs) that are used to treat epilepsy and some other conditions are associated with a range of cutaneous side...
Supervisor: Professor Patrick Kwan
Treatment Gap in People with Newly Diagnosed Epilepsy in Australia
Epilepsy is one of the most common serious chronic neurological disorders and is estimated to affect approximately 68 million people worldwide....
Supervisor: Professor Patrick Kwan
Voices of neurons
From networks of interconnected neurons emerge complex non-linear dynamics. These dynamics can be difficult to interpret and classify. Conventional...
Supervisor: Professor Patrick Kwan
Wearable devices for non-invasive, ambulatory seizure monitoring and prediction
The development of reliable, accurate, non-invasive methodologies for continuous, long-term seizure monitoring is a critical part of the precision...
Supervisor: Professor Patrick Kwan
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