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Predictors and mechanisms of cutaneous adverse drug reactions: a multi-omic approach

Description 
Mainstream anti-epileptic drugs (AEDs) that are used to treat epilepsy and some other conditions are associated with a range of cutaneous side effects. Genetic analyses that compare the genomes of those who develop an adverse reaction with those that are tolerant to AEDs has identified specific genetic markers that increase susceptibility in some but not all individuals. It is increasingly understood that multiple genomic and /or environmental factors contribute to drug sensitivity. A better understanding of the underlying molecular mechanisms will enhance capacity for personalised treatment and the design of safer drugs. This project represents a unique opportunity to investigate the underlying molecular mechanisms by integrating genomic analysis with transcriptomics (gene expression) approaches. The transcriptome, derived from T-cells, will be used to identify genes that are differentially expressed or that change their pattern of co-expression in cells from drug-exposed cases as compared to those from drug-tolerant controls. The student will be part of a multidisciplinary team with expertise in neurology, cell biology and bioinformatics and gain an understanding of the rapidly evolving field of pharmacogenomics.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
skin reactions, pharmacogenomics
School 
Central Clinical School
Available options 
PhD/Doctorate
Masters by Research
Honours
BMedSc(Hons)
Time commitment 
Full-time
Physical location 
AMREP
Co-supervisors 
Dr 
Alison Anderson

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