Research Projects
Eukaryotic transcriptional co-activators are multi-subunit complexes that both modify chromatin and recognize histone modifications to control gene...
Supervisor: Dr Dominika Elmlund
The immune system comprises a variety of effector cells that are uniquely poised to recognize infected or transformed cells. However, the capacity of...
Supervisor: Dr Richard Berry
The majority of cancer deaths are attributed to metastases rather than the primary tumour. Therefore, the development of new therapeutics targeting...
Supervisor: Associate Professor Andrew Ellisdon
Viruses and pathogens are part of day-to-day encounters that the immune system needs to deal with. How the immune system “sees”, recognises and...
Supervisor: Assoc Professor Stephanie Gras
In this project, in collaboration with Professor Ross Hannan (ANU), we will study the structure of Upstream Binding Factor (UBF) in complex with...
Supervisor: Professor James Whisstock
SAGA’s many functions are essential for normal embryo development in flies and mice. Mutation or altered expression of SAGA subunits are associated...
Supervisor: Dr Hans Elmlund
Like many developed countries, the population of Australia is ageing; with 13.8% of the population currently over the age of 65 and predictions this...
Supervisor: Professor Nicole La Gruta
Post-translational modification of joint proteins leads to the generation of autoantigenic peptides that drive the inflammatory response in...
Supervisor: Dr Hugh Reid
In celiac disease (CD), the T cell response to gliadin peptides derived from gluten in from wheat, barley and rye has been well characterised....
Supervisor: Dr Hugh Reid
Viruses and humans have coevolved for millions of years and during this time viruses have armed themselves with strategies to hijack or evade our...
Supervisor: Dr Natalie Borg
DC monitor the environment for potential “danger signals” that signify pathogen invasion, including non-homeostatic cell death caused by viruses. We...
Supervisor: Assoc Professor Mireille Lahoud
The enigmatic receptor KIR2DL5.
KIR2DL5 is the least understood member of the KIR family. By sequence, KIR2DL5 is a hybrid of KIR3DL1 (see Vivian...
Supervisor: Mr Julian Vivian
The presentation of post-translationally modified (PTM) peptides by cell surface MHC molecules increases the diversity of targets for recognition by...
Supervisor: Dr Nathan Croft
Our mothers programed the first decisions of our lives by mRNA dumping: the regulated translation of this maternal transcriptome controls the first...
Supervisor: A/Prof Traude Beilharz
Monoclonal antibodies (mAbs) that block checkpoint inhibitory receptors including Programmed Death (PD)-1 act directly on T cells to overcome ‘...
Supervisor: Assoc Professor Meredith O'Keeffe
All living things respond to changes in their direct environment by evoking innate stress response mechanisms. Multiple factors, including those...
Supervisor: Dr Kylie Wagstaff
Small noncoding RNAs are increasingly recognised as important regulators of gene expression and genome integrity across all kingdoms of life. This is...
Supervisor: Dr Peter Boag
The tyrosine kinase Src was the first proto-oncogene to be identified, and it is now known that Src plays an important role in several human cancers...
Supervisor: Professor Roger Daly
We are performing in-depth characterization of the microenvironment of human tumours, and discovering new mechanisms used by these cells to influence...
Supervisor: Dr Anne Fletcher
Single cell technologies are being rapidly adopted and accordingly, there is a high demand for intuitive tools and software that help with the...
Supervisor: Professor Nicholas Huntington