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Research Projects

Frequent resistance to single-agent treatment means that doctors are turning to combination therapy, i.e. ‘cocktails of drugs’, to beat resistance....
Supervisor: Dr Lan Nguyen

This project aims to engineer new biomaterials that can permanently integrate with the brain. This project expects to generate new knowledge using...

Pleurotolysin: a pore forming toxin from the carnivorous oyster mushroom

Putting the brakes on inflammation: Using the structure of important immune protein receptors to develop therapeutics

Over the past years, our scientific and clinical research team has pursued basic discovery and preclinical research into the skin autoimmune disease...
Supervisor: Dr. Asolina Braun

Gamma-aminobutyric acid (GABA) produced by Glutamic Acid Descarboxylase (GAD) is the most abundant neurotransmitter inhibitor in the CNS and is...

Here we will combine omics technologies with novel muscle-specific gene manipulation technologies to discover novel signalling pathways controlling...
Supervisor: Dr Adam Rose

Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory...

The Bcl-2 family of proteins is crucial for apoptosis (a form of programmed cell death) regulation. The Bcl-2 proteins are synthesized in cytosolic...

Inflammation is the body’s response to injury or infection. A key feature of inflamed tissues is the accumulation of leukocytes (white blood cells),...

Eukaryotic transcriptional co-activators are multi-subunit complexes that both modify chromatin and recognize histone modifications to control gene...
Supervisor: Dr Dominika Elmlund

The immune system comprises a variety of effector cells that are uniquely poised to recognize infected or transformed cells. However, the capacity of...
Supervisor: Dr Richard Berry

Viruses and pathogens are part of day-to-day encounters that the immune system needs to deal with. How the immune system “sees”, recognises and...

In this project, in collaboration with Professor Ross Hannan (ANU), we will study the structure of Upstream Binding Factor (UBF) in complex with...

SAGA’s many functions are essential for normal embryo development in flies and mice. Mutation or altered expression of SAGA subunits are associated...
Supervisor: Dr Hans Elmlund

Like many developed countries, the population of Australia is ageing; with 13.8% of the population currently over the age of 65 and predictions this...

Post-translational modification of joint proteins leads to the generation of autoantigenic peptides that drive the inflammatory response in...
Supervisor: Dr Hugh Reid

In celiac disease (CD), the T cell response to gliadin peptides derived from gluten in from wheat, barley and rye has been well characterised....
Supervisor: Dr Hugh Reid

Viruses and humans have coevolved for millions of years and during this time viruses have armed themselves with strategies to hijack or evade our...
Supervisor: Dr Natalie Borg

DC monitor the environment for potential “danger signals” that signify pathogen invasion, including non-homeostatic cell death caused by viruses. We...

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