Research Projects
Two key pathways controlling amino acid homeostasis are the cellular sensors mTOR and GCN2 but these cannot be the only ones. Here using cell based...
Supervisor: Dr Adam Rose
One of the most recognised risk factors for cardiovascular disease is hypertension. Cardiac fibrosis is at the centre of many pathological conditions...
Supervisor: Professor Mibel Aguilar
Background
Nuclear transport is central to eukaryotic cell processes such as signal transduction and differentiation, where changes in transcription...
Supervisor: Professor David Jans
Nuclear transport inhibitors to combat diseases
Two major health burdens world-wide are cancer and infectious diseases like viral illnesses and...
Supervisor: Professor David Jans
Bacteria are embroiled in a constant struggle with virulent bacteriophages. This battle for survival spans millions of years of evolution. Throughout...
Supervisor: Dr Gavin Knott
Primary liver cancer is one of the world’s deadliest cancers and the third most common cause of cancer death. Hepatocellular carcinoma (HCC)...
Supervisor: Professor Tony Tiganis
Hepatocellular carcinoma (HCC) is one of the most fatal and fastest growing cancers. In recent years, non-alcoholic steatohepatitis (NASH) has been...
Supervisor: Professor Colby Zaph
Cubosomes have attracted widespread attention in the pharmaceutical industry due to their high stability, ability to contain amphiphilic drugs,...
Supervisor: Nanoantibiotics - SHEN LAB
Frequent resistance to single-agent treatment means that doctors are turning to combination therapy, i.e. ‘cocktails of drugs’, to beat resistance....
Supervisor: Dr Lan Nguyen
This project aims to engineer new biomaterials that can permanently integrate with the brain. This project expects
to generate new knowledge using...
Supervisor: Professor Mibel Aguilar
Pleurotolysin: a pore forming toxin from the carnivorous oyster mushroom
Supervisor: Assoc Professor Michelle Dunstone
Protein-RNA interactions are integral to cellular biology – both in normal cellular function and also in cells subject to the stresses of viral...
Supervisor: Assoc Professor Jackie Wilce
Putting the brakes on inflammation: Using the structure of important immune protein receptors to develop therapeutics
Supervisor: Assoc Professor Michelle Dunstone
Over the past years, our scientific and clinical research team has pursued basic discovery and preclinical research into the skin autoimmune disease...
Supervisor: Dr. Asolina Braun
Gamma-aminobutyric acid (GABA) produced by Glutamic Acid Descarboxylase (GAD) is the most abundant neurotransmitter inhibitor in the CNS and is...
Supervisor: Professor James Whisstock
Here we will combine omics technologies with novel muscle-specific gene manipulation technologies to discover novel signalling pathways controlling...
Supervisor: Dr Adam Rose
Natural killer (NK) cells are the founding members of the innate lymphoid cell family and contribute to the rapid production of inflammatory...
Supervisor: Professor Nicholas Huntington
The Bcl-2 family of proteins is crucial for apoptosis (a form of programmed cell death) regulation. The Bcl-2 proteins are synthesized in cytosolic...
Supervisor: Professor Mibel Aguilar
Inflammation is the body’s response to injury or infection. A key feature of inflamed tissues is the accumulation of leukocytes (white blood cells),...
Supervisor: Assoc Professor Martin Stone
Alternative splicing is a regulatory pathway that can can change the messenger RNA produced from a gene and subsequently the proteins that are...
Supervisor: Dr Carlos Rosado