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Research Projects

The gastric carcinogenic bacterium Helicobacter pylori has a unique ability to withstand high acidity of the stomach by buffering its periplasm at pH...

Female fertility and offspring health are critically dependent on the maintenance of an adequate supply of high quality oocytes. Little is known...
Supervisor: Dr Jessica Stringer

Worryingly, exposure to toxic contaminants released into the air and water supply have been shown to negatively affect fertility. It is important to...
Supervisor: Dr Amy Winship

Type 2 diabetes and coronary artery disease (CAD) are two closely related chronic diseases with a high prevalence worldwide. Both diseases share...

Exosomes are small vesicles (50-150 nm in size) secreted by most cell types and are involved in cell - cell communication and regulation of immune...
Supervisor: Professor Brian Cooke

In several cancer types, a higher tumour mutational burden (TMB) has been associated with increased immune cell infiltration into tumours and better...

The discovery of giant viruses, comparable in size and complexity to simple cellular organisms has pushed back the frontier of the virus world....

Society urgently needs new therapeutic strategies to tackle multi-drug resistant (MDR) bacterial infections. Current serious bacterial pathogens...
Supervisor: Dr Julien Tailhades

The Hippo/YAP signalling pathway is frequently dysregulated (~80%) in breast cancer. Yet, efforts aimed at targeting this pathway for therapeutic...
Supervisor: Dr Lan Nguyen

Diversity is one of the most highly evaluated value in our workplace to maximize its performance. Diversity in neural cells (neurons) may be...
Supervisor: Dr Tatsuo Sato

Anti-mullerian Hormone (AMH) or Mullerian Inhibiting Substance (MIS) is fundamentally known for its crucial activities in gonadal development during...
Supervisor: Dr Kelly Walton

The treatment of bacterial infections in humans and animals has largely relied on the use of antibiotics for over 70 years. One consequence of the...
Supervisor: Professor Dena Lyras

The control of stem cell division and differentiation is crucial to ensure correct development of an embryo and to maintain tissue homeostasis during...

This project ewill fucntionally analyse novel genes found to be expressed in embryonic chicken gonads. Methods include standard and cutting edge...

The human genome is dominated by non-protein encoding information. Indeed, the differences between humans and other animals cannot be accounted for...

Small cell lung cancer (SCLC) is an incredibly aggressive form of lung cancer with limited treatment options, begging the need for major therapeutic...

Our group focuses of studying dendritic cells (DC) by analysing the cell surface receptors they express with the view that these receptors contribute...

The MACPF/CDC family proteins use a common fold to oligomerise into a ring-shaped transmembrane pore capable of either direct cell lysis or passive...

The eukaryotic genome consists of two classes of genes preceded by distinctly different promoter sequences. Housekeeping genes (90%) code for...
Supervisor: Dr Hans Elmlund

Gastric cancer is a leading cause of cancer-related death, claiming more than 1 million lives annually. A major predisposing factor to developing...
Supervisor: Dr Dustin Flanagan

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