Research Projects
Society urgently needs new therapeutic strategies to tackle multi-drug resistant (MDR) bacterial infections. Current serious bacterial pathogens...
Supervisor: Dr Julien Tailhades
The Hippo/YAP signalling pathway is frequently dysregulated (~80%) in breast cancer. Yet, efforts aimed at targeting this pathway for therapeutic...
Supervisor: Dr Lan Nguyen
Diversity is one of the most highly evaluated value in our workplace to maximize its performance. Diversity in neural cells (neurons) may be...
Supervisor: Dr Tatsuo Sato
Anti-mullerian Hormone (AMH) or Mullerian Inhibiting Substance (MIS) is fundamentally known for its crucial activities in gonadal development during...
Supervisor: Dr Kelly Walton
The treatment of bacterial infections in humans and animals has largely relied on the use of antibiotics for over 70 years. One consequence of the...
Supervisor: Professor Dena Lyras
The control of stem cell division and differentiation is crucial to ensure correct development of an embryo and to maintain tissue homeostasis during...
Supervisor: Professor Roger Pocock
This project ewill fucntionally analyse novel genes found to be expressed in embryonic chicken gonads.
Methods include standard and cutting edge...
Supervisor: Assoc Professor Craig Smith
Antigen presentation is the fundamental and complex process in which a cell breaks down proteins into small fragments (peptides) and presents these...
Supervisor: Chen Li
The human genome is dominated by non-protein encoding information. Indeed, the differences between humans and other animals cannot be accounted for...
Supervisor: Prof Traude Beilharz
Small cell lung cancer (SCLC) is an incredibly aggressive form of lung cancer with limited treatment options, begging the need for major
therapeutic...
Supervisor: Professor Nicholas Huntington
The MACPF/CDC family proteins use a common fold to oligomerise into a ring-shaped transmembrane pore capable of either direct cell lysis or passive...
Supervisor: Assoc Professor Michelle Dunstone
Injury creates a fertile environment allowing for plasticity mechanisms to shape recovery. The ability of the brain to reorganize synaptic...
Supervisor: Dr Nafiseh Atapour
Skeletal muscle is the largest tissue by mass in the human body and yet there is a major clinical gap in the lack of treatments for diseased muscle....
Supervisor: Meagan McGrath
Cells need to know when enough nutrients and lipids are available to grow. Our recent work identified GPR155 as an unexpected cholesterol-sensing...
Supervisor: Professor Andrew Ellisdon
Gastric cancer is a leading cause of cancer-related death, claiming more than 1 million lives annually. A major predisposing factor to developing...
Supervisor: Dr Dustin Flanagan
Cells constantly monitor nutrients and energy levels to decide whether to grow, divide or recycle their contents. A major control point for this...
Supervisor: Professor Andrew Ellisdon
The U.S. Food and Drug Administration (FDA) designated psilocybin as a “breakthrough therapy” in 2018 based on its efficacy in treatment-resistant...
Supervisor: Dr Claire Foldi
Developing tumour cells interact with a complex and heterogeneous ecosystem, namely the tumour microenvironment (TME), comprising mutant and wild-...
Supervisor: Dr Dustin Flanagan
This exciting project will use genetic techniques to identify mechanisms that control brain development in the Caenorhabditis elegans model. The C....
Supervisor: Professor Roger Pocock
Polycystic Kidney Disease (PKD) is a genetically heterogeneous disease characterised by the formation of multiple fluid-filled renal cysts which...
Supervisor: Dr Denny Cottle