Research Projects
Background: Heart failure remains a major cause of morbidity and mortality despite significant advances in treatment. Patients with heart failure...
Supervisor: Professor Morag J. Young
The mineralocorticoid receptor (MR) is an established therapeutic target for heart disease. However current drugs are not selective for the heart and...
Supervisor: Professor Morag J. Young
Regulating the receptors: new targets for fine-tuning hormone receptor actions in health and disease
Steroid hormone receptors (nuclear receptors) are expressed in many tissues and act as transcription factors to control cellular and tissue function...
Supervisor: Professor Morag J. Young
The mineralocorticoid receptor (MR) is a ligand activated transcription factor that is important for physiological control of blood pressure and...
Supervisor: Professor Morag J. Young
Background: Current MR antagonists are among the most effective therapies for heart failure, yet their use remains constrained by adverse renal...
Supervisor: Professor Morag J. Young
Background: Heart failure, diabetes and chronic kidney disease affect millions of people worldwide and are characterised by persistent inflammation...
Supervisor: Professor Morag J. Young