Research Projects
Post-translational modification of joint proteins leads to the generation of autoantigenic peptides that drive the inflammatory response in...
Supervisor: Dr Hugh Reid
In celiac disease (CD), the T cell response to gliadin peptides derived from gluten in from wheat, barley and rye has been well characterised....
Supervisor: Dr Hugh Reid
Viruses and humans have coevolved for millions of years and during this time viruses have armed themselves with strategies to hijack or evade our...
Supervisor: Dr Natalie Borg
DC monitor the environment for potential “danger signals” that signify pathogen invasion, including non-homeostatic cell death caused by viruses. We...
Supervisor: Assoc Professor Mireille Lahoud
The enigmatic receptor KIR2DL5.
KIR2DL5 is the least understood member of the KIR family. By sequence, KIR2DL5 is a hybrid of KIR3DL1 (see Vivian...
Supervisor: Mr Julian Vivian
The presentation of post-translationally modified (PTM) peptides by cell surface MHC molecules increases the diversity of targets for recognition by...
Supervisor: Dr Nathan Croft
Our mothers programed the first decisions of our lives by mRNA dumping: the regulated translation of this maternal transcriptome controls the first...
Supervisor: A/Prof Traude Beilharz
Monoclonal antibodies (mAbs) that block checkpoint inhibitory receptors including Programmed Death (PD)-1 act directly on T cells to overcome ‘...
Supervisor: Assoc Professor Meredith O'Keeffe
All living things respond to changes in their direct environment by evoking innate stress response mechanisms. Multiple factors, including those...
Supervisor: Dr Kylie Wagstaff
Small noncoding RNAs are increasingly recognised as important regulators of gene expression and genome integrity across all kingdoms of life. This is...
Supervisor: Dr Peter Boag
The tyrosine kinase Src was the first proto-oncogene to be identified, and it is now known that Src plays an important role in several human cancers...
Supervisor: Professor Roger Daly
We are performing in-depth characterization of the microenvironment of human tumours, and discovering new mechanisms used by these cells to influence...
Supervisor: Dr Anne Fletcher
Single cell technologies are being rapidly adopted and accordingly, there is a high demand for intuitive tools and software that help with the...
Supervisor: Professor Nicholas Huntington
The adaptive arm of immune system uses lymphocytes to generate antibody and memory responses to challenges throughout life. Three lineages of...
Supervisor: Dr Martin Davey
Natural killer (NK) cells are effector lymphocytes of the innate immune system that are known for their ability to kill transformed and virus-...
Supervisor: Professor Nicholas Huntington
When mitochondria are unable to function properly, the proteome changes to re-establish homeostasis. In this project, we will investigate why some...
Supervisor: Dr Luke Formosa
Trauma and uncontrolled bleeding is a major cause of morbidity worldwide. We have developed and structurally characterized potent monoclonal...
Supervisor: Professor James Whisstock
The project will use live cell imaging, molecular cell biology and infection models to understand how Candida albicans evades innate immune...
Supervisor: Assoc Professor Ana Traven
Complex I of the mitochondrial respiratory chain is a huge machine containing 44 different subunits. Following up on recent studies, (Formosa et al...
Supervisor: Dr Luke Formosa