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Research Projects

Dysfunctional feeding behaviour encompasses energy overconsumption (obesity, binge eating) to malnutrition (unhealthy food choices, excessive dieting...

Heme is an essential nutrient for the bacterial pathogen Haemophilus influenzae, which causes serious respiratory infections, otitis media and...
Supervisor: Dr Rhys Grinter

We are performing in-depth characterization of the microenvironment of human tumours, and discovering new mechanisms used by these cells to influence...
Supervisor: Dr Anne Fletcher

Development of therapeutic antibodies to treat human diseases

The oocyte-secreted TGF-beta proteins, BMP15 and GDF9, are essential for the acquisition of oocyte developmental competence during folliculogenesis....

The oocyte-secreted factors, bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), are essential for the acquisition of...
Supervisor: Dr Kelly Walton

The thymus is primarily responsible for generating naïve, self-tolerant T cells from hematopoietic precursors. However, deterioration of thymic...

Single cell technologies are being rapidly adopted and accordingly, there is a high demand for intuitive tools and software that help with the...

The adaptive arm of immune system uses lymphocytes to generate antibody and memory responses to challenges throughout life. Three lineages of...
Supervisor: Dr Martin Davey

Natural killer (NK) cells are effector lymphocytes of the innate immune system that are known for their ability to kill transformed and virus-...

When mitochondria are unable to function properly, the proteome changes to re-establish homeostasis. In this project, we will investigate why some...
Supervisor: Dr Luke Formosa

Iron is essential for bacterial growth, but it is severely limited in most environments. Bacteria have evolved clever systems to acquire this...
Supervisor: Dr Francesca Short

Trauma and uncontrolled bleeding is a major cause of morbidity worldwide. We have developed and structurally characterized potent monoclonal...

Pseudomonas aeruginosa is a Gram-negative bacterium that is one of the most common pathogens of people with cystic fibrosis. This organism causes...

Pulmonary hypertension is a disease of high blood pressure in the lungs, which leads to increased right ventricular afterload, remodelling and...
Supervisor: Dr Kristen Bubb

The Mpox virus is endemic in West and Central African countries. In 2022, the WHO declared Mpox a global health emergency as infections have spread...
Supervisor: Dr Gabriela Khoury

The project will use live cell imaging, molecular cell biology and infection models to understand how Candida albicans evades innate immune...

Complex I of the mitochondrial respiratory chain is a huge machine containing 44 different subunits. Following up on recent studies, (Formosa et al...
Supervisor: Dr Luke Formosa

Mitochondria more than just “the powerhouse of the cell”. They are fascinating, highly dynamic organelles that carry out an array of cellular...
Supervisor: Dr Kate McArthur

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