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Research Projects

CHEK2 is an established breast cancer predisposition gene. Pathogenic variants in CHEK2 are associated with a 3-fold increased risk of breast cancer...

PALB2 plays a role in homologous recombination repair of DNA double-strand damage. Loss-of-function germline variants in PALB2 are associated with a...

The currently identified genetic prostate cancer risk factors account for less than 40% of the familial risk for the disease. Very few of these...