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Research Projects

Heart failure occurs when the heart muscle weakens and is unable to pump enough blood to meet the body’s needs. It is a major public health issue,...

The mineralocorticoid receptor (MR) is an established therapeutic target for heart disease. However current drugs are not selective for the heart and...

Steroid hormone receptors (nuclear receptors) are expressed in many tissues and act as transcription factors to control cellular and tissue function...

The mineralocorticoid receptor (MR) is a ligand activated transcription factor that is important for physiological control of blood pressure and...

Virtually all cardiac functions, including the incidence of atrial fibrillation (AF) follow a circadian rhythm. Loss of appropriate timing keeping...

Class IA PI3Ks are activated by receptor tyrosine kinase receptors and are critical regulators of adaptive heart growth and cardiac protection under...

Patients with diabetes are disproportionally affected by the incidence of cardiovascular disease (CVD); diabetic cardiac myopathy (DCM) affects ~20-...