Research Projects
Alternative splicing is a regulatory pathway that can can change the messenger RNA produced from a gene and subsequently the proteins that are...
Supervisor: Professor Merlin Thomas
The objective of this project is to gain a deeper understanding of the regulation of glyoxalase (GLO1), an enzyme that plays a crucial role in...
Supervisor: Dr Carlos Rosado
Need for a novel solution.
Despite advances in the treatment of atherosclerotic cardiovascular disease (CVD), the risk of CVD remains higher in...
Supervisor: Dr Waheed Khan
Background:
Over 400,000 Australians are affected by diabetic kidney disease. Current clinical therapies only delay the progression to end stage...
Supervisor: Assoc Professor Melinda Coughlan
This project seeks to comprehensively characterize our prototype inhibitor of CDA1, CHA-061, for its treatment effect on diabetes associated kidney...
Supervisor: Dr Zhong-Lin Chai
This project seeks to comprehensively characterize our prototype inhibitor of CDA1, CHA-061, for its treatment effect on diabetes associated kidney...
Supervisor: Dr Zhong-Lin Chai
Diabetes and its complications are arguably the epidemic of this century. The number of individuals with diabetes has doubled over the last 20 years...
Supervisor: Assoc Professor Melinda Coughlan
S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often form heterodimers,...
Supervisor: Dr Carlos Rosado
Background: Advanced glycation endproducts (AGEs), formed via the processing of foods, are a major constituent of our modern convenience diet....
Supervisor: Assoc Professor Melinda Coughlan
The development of diabetic complications including vascular and renal disease is enhanced in diabetic patients. However, the underlying mechanism as...
Supervisor: Dr Jay C. Jha
Inflammatory pathways are a key contributor to diabetic vascular disease, including atherosclerosis. Underlying the development of vascular disease...
Supervisor: Dr Phillip Kantharidis
Atherosclerosis is a major contributor to cardiovascular disease (CVD) related premature deaths in people with diabetes. Residual increased risk of...
Supervisor: Dr Waheed Khan
Alternative splicing is a regulatory pathway that can can change the messenger RNA produced from a gene and subsequently the proteins that are...
Supervisor: Dr Carlos Rosado
Atherosclerosis is a major contributor to cardiovascular disease (CVD) related deaths in subjects with diabetes. Residual increased risk of CVD...
Supervisor: Dr Waheed Khan
Diabetic kidney disease is an important complication of diabetes and remains a huge medical burden and a major contributor of morbidity and mortality...
Supervisor: Dr Phillip Kantharidis
The development of diabetic complications including vascular and renal disease is enhanced in diabetic patients. However, the underlying mechanism as...
Supervisor: Dr Jay C. Jha
This project seeks to further improve the behavior of our prototype peptide inhibitor CHA-061 against the profibrotic effect of CDA1. CHA-061 is a...
Supervisor: Dr Zhong-Lin Chai
The Department of Diabetes at the School of Translational Medicine (STM) is a part of Monash University’s Faculty of Medicine, Nursing and Health...
Supervisor: Assoc Professor Melinda Coughlan