Research Projects
The eukaryotic genome consists of two classes of genes preceded by distinctly different promoter sequences. Housekeeping genes (90%) code for...
Supervisor: Dr Dominika Elmlund
The academic research program within this laboratory is focused on defining the key molecular interactions underlying receptor recognition events...
Supervisor: Professor Jamie Rossjohn
A major challenge in cancer therapeutics is to kill tumour cells without harming normal cells in the body. Traditional chemotherapy tries to do this...
Supervisor: Dr Lan Nguyen
Cancer therapy and oncology has entered a new exciting era of targeted therapy and personalised patient treatment, but resistance and tumour...
Supervisor: Dr Lan Nguyen
In recent years, the landscape of cancer therapy has shifted dramatically. Novel approaches based on harnessing the patient’s own immune system have...
Supervisor: MICHAEL CHOPIN, PHD
Psoriasis is a skin autoimmune disease that affects 2-3% of the global population. Around half of the patients carry the major risk gene for...
Supervisor: Dr. Asolina Braun
Studies in the Ryan lab involve understanding how protein complexes are built and how mutations in proteins cause defects in assembly. Our models are...
Supervisor: Professor Mike Ryan
This project aims to determine the molecular structure of the interface between novel peptide self-assemblies and
cell membranes through x-ray...
Supervisor: Professor Mibel Aguilar
Bacteria secrete vesicles that traffic toxins to mitochondria of macrophages. This project will investigate how vesicle-delivered toxins kill...
Supervisor: Dr Thomas Naderer
Single-cell analyses are at the leading edge of technological development for cell biology. And, transcriptomics analyses at single-cell resolution...
Supervisor: A/Prof Traude Beilharz
Our research program is focused on fibroblast-like stromal cells found in secondary lymphoid organs and tumours. These cells create the structure on...
Supervisor: Dr Anne Fletcher
This project will investigate the machinery involved in mitochondrial fission and fusion and the relationship between mitochondrial dynamics and...
Supervisor: Professor Mike Ryan
It is now well-established that the cancer stroma, including cancer-associated fibroblasts, plays a major role in development and progression of this...
Supervisor: Professor Roger Daly
Given their natural adjuvant properties, and their unique attributes in promoting T cell priming and recruitment into solid tumors, dendritic cells (...
Supervisor: MICHAEL CHOPIN, PHD
It is now well appreciated that adipocytes are not simply fat storage cells, but can be subdivided into white, brown and ‘beige’ cells, with the...
Supervisor: Professor Tony Tiganis
We have discovered that the initiation of a TCR signal in Treg cells entails docking of the Treg TCR in the opposite orientation to that observed for...
Supervisor: Dr Hugh Reid
Natural killer (NK) cell activity is essential for initiating antitumor responses and may be linked to immunotherapy success. NK cells and other...
Supervisor: Professor Nicholas Huntington
The PI3K-Akt-mTOR signalling network plays a pivotal role in the regulation of cell growth and proliferation, and is highly complex with multiple...
Supervisor: Dr Lan Nguyen
Cryo-electron tomography (CET) allows for the highest resolution cellular imaging possible at the moment. To get access to all areas of the cell we...
Supervisor: Dr Georg Ramm
Gastric cancer kills ~1 million people worldwide each year and has an average 5-year survival rate of 19%. It is, therefore, a cancer of unmet need....
Supervisor: Dr Dustin Flanagan