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Research Projects

Stem cell models of kidney development and disease, live imaging, bioinformatics
The Combes laboratory has opportunities for postgraduate research projects in animal and stem cell models of kidney development and disease, advanced...
Supervisor: Dr Alex Combes
Stem cell therapy to reverse kidney disease due to diabetes
The prevalence of diabetes mellitus continues to increase worldwide leading to premature mortality. About 30% of patients with type 2 diabetes (T2D)...
Supervisor: Professor Sharon Ricardo
TAGing APP promotes Alzheimer’s disease pathogenesis by containing adult neurogenesis
Neurogenesis describes the fundamental process of generating neurons that integrate into existing circuits. Although originally thought to cease...
Supervisor: Professor Zhi-Cheng Xiao
Targeting ribosome biosynthesis in prostate cancer
The transcript encoding the proto-oncogene MYC is commonly overexpressed in prostate cancer (PC). MYC protein abundance is also increased in the...
Supervisor: Dr Luc Furic
Teeth, wear and environment: how diet influenced early human evolution
Background: Strong climatic changes may have been the primary drivers of human evolution. Understanding how early human (hominin) foraging and...
Supervisor: A/Prof Luca Fiorenza
The dimensionality problem of membrane protrusions
Thin, flat, branched actin cytoskeleton filled membrane protrusions like the lamellipodia and membrane ruffles are utilized by cells for a plethora...
Supervisor: Dr Senthil Arumugam
The effect of feeding behaviour on the biomechanics of the primate jaw during ontogeny
The shape of the lower jaw (mandible) and dentition in non-human primates varies between species but the reasons behind this morphological variation...
Supervisor: Dr Olga Panagiotopoulou
The role of Smad3 acetylation in organ fibrosis
This study investigates the role of Smad3 acetylation in the development and progression of organ/tissue fibrosis.
Supervisor: Assoc Professor Jinhua Li
Thymic epithelial stem cell niche
The thymus is primarily responsible for generating naïve, self-tolerant T cells from hematopoietic precursors. However, deterioration of thymic...
Supervisor: Assoc Professor Ann Chidgey
Understanding the pathogenesis of polycystic kidney disease
Background: Polycystic kidney disease (PKD) is the most common potentially lethal Mendelian disease, affecting around 1/1000 people. It arises when...
Supervisor: Assoc Professor Ian Smyth
Using hormones to treat cancer
Prostate cancer is a global health challenge. Many patients with prostate cancer have positive outcomes, but some patients develop aggressive tumours...
Supervisor: Dr Mitchell Lawrence
Watching the Hippo pathway in real time in growing organs
A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have...
Supervisor: Professor Kieran Harvey

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