Understanding the biology of cellular aging and identification of novel approaches to control it

Cellular aging is a complex biological process involving a gradual decline in cellular function and increased vulnerability to disease. It is associated with a range of age-related disorders, including cancer, cardiovascular disease, and neurodegeneration. Despite extensive research, many aspects of cellular aging and its underlying mechanisms remain poorly understood. In this project, we aim to uncover the molecular mechanisms that drive cellular ageing and identify key pathways that could be targeted for intervention. In addition, we will aim to address how cells respond to stress events (eg. inflammation or oxidative stress); what happens that in response to stress events some cells may die, some may go to senescence and some may repair ad continue proliferation. This project will utilise a variety of experimental techniques, including cell culture, microscopic analysis, RNA/protein analysis, proteomics and pharmacological/genetic manipulations. We work with natural ageing models, as well as accelerated ageing models that we have developed in the lab.