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Uncovering the novel phenotype of macrophages in the testis

Description 
Mouse testicular macrophages have several unique functional properties associated with testicular immune privilege. These cells have an alternatively activated phenotype that creates an environment whereby cell-mediated immune responses are tightly controlled. The intratesticular mechanisms responsible for directing the maturation of the testicular macrophages, and their functional consequences need to be investigated. In this project, monocytes isolated from blood will be matured in culture in the presence of putative testicular macrophage-regulating factors, such as activin and testosterone, in order to understand the relative importance of the testicular environment in creating the unique testicular macrophage phenotype. Students undertaking this project at postgraduate level may also have the opportunity to undertake 6-12 months collaborative research at the Justus Liebig University in Giessen, Germany, with the option of studying for a joint degree award from both Universities.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
Inflammation, men's health, fertility, testis, immunoregulation, macrophages
School 
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research
Available options 
PhD/Doctorate
Masters by research
Honours
Time commitment 
Full-time
Part-time
Physical location 
Monash Health Translation Precinct (Monash Medical Centre)
Co-supervisors 
Dr 
Rukmali Wijayarathna

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