Mouse testicular macrophages have several unique functional properties associated with testicular immune privilege. These cells have an alternatively activated phenotype that creates an environment whereby cell-mediated immune responses are tightly controlled. The intratesticular mechanisms responsible for directing the maturation of the testicular macrophages, and their functional consequences need to be investigated. In this project, monocytes isolated from blood will be matured in culture in the presence of putative testicular macrophage-regulating factors, such as activin and testosterone, in order to understand the relative importance of the testicular environment in creating the unique testicular macrophage phenotype. Students undertaking this project at postgraduate level may also have the opportunity to undertake 6-12 months collaborative research at the Justus Liebig University in Giessen, Germany, with the option of studying for a joint degree award from both Universities.
Inflammation, men's health, fertility, testis, immunoregulation, macrophages
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research
Masters by research
Monash Health Translation Precinct (Monash Medical Centre)