Description
Inflammatory skin diseases may leave persistent molecular imprints even after visible inflammation has resolved. This project investigates how immune, epithelial, stromal and endothelial cells retain disease-associated transcriptional or epigenetic programs that may contribute to relapse, chronic inflammation, altered tissue responses and differences in therapeutic response.
Techniques include skin biopsy processing, single-cell or single-nucleus preparation, RNA/DNA extraction, scRNA-seq, snRNA-seq, scATAC-seq, multiome RNA+ATAC, spatial transcriptomics, cell-state analysis, chromatin accessibility analysis and gene-regulatory network inference. This project is mainly bioinformatics-based; coding experience in R and related single-cell analysis tools is preferred.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
dermatology; skin immunology; cutaneous biology; barrier immunity; inflammatory skin disease; atopic dermatitis; skin microbiome; ; cutaneous microbiome; host–microbe interactions; single-cell; spatial transcriptomics; epigenomics; transcriptomics; metagenomics; multi-omics; R programming; bioinformatics; computational immunology; systems biology
School
School of Translational Medicine » Immunology and Pathology
Available options
PhD/Doctorate
Masters by research
BMedSc(Hons)
Joint PhD/Exchange Program
Time commitment
Full-time
Top-up scholarship funding available
No
Physical location
Alfred Hospital
Co-supervisors
Prof
Johannes Kern