Fatal influenza virus infections in humans and mice are associated with hyperinflammation and there are currently no effective treatments available. While innate immune responses elicited in response to influenza viruses are important for fighting infection, responses need to be tightly regulated to limit tissue damage and the development of disease. Understanding how the innate immune system responds to different strains of influenza virus is of great importance and may provide insight into the mechanisms involved in the development of disease. For example, we have identified that in mice, innate immune inflammasomes play both a protective and detrimental role at different stages of infection. This project aims to examine pathways involved in the induction of inflammation using in vitro and in vivo models of influenza virus infection and a range of techniques. These studies will allow the development of novel therapeutics to treat severe influenza virus infections.
innate immunity, viral disease, influenza, inflammation, primary human cells
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research
Top-up scholarship funding available
Monash Health Translation Precinct (Monash Medical Centre)