Description
The Harley laboratory has identified a sex reversed XY female patient with early onset Parkinson’s disease (PD). Through whole exome sequencing, it was discovered that this patient harbours a missense mutation in ERβ. Due to estrogen’s important functions in both sex determination and in neuroprotection, it is suggested that this mutation might have a function in both aspects of this patient’s unusual phenotype. This project will investigate the function of the ERβ variant in in vitro models of Parkinson's disease and gonadal development.
Essential criteria:
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords
Parkinson's disease, sex reversal, testis, ERβ
School
School of Clinical Sciences at Monash Health / Hudson Institute of Medical Research » Molecular and Translational Sciences
Available options
PhD/Doctorate
Masters by research
Honours
BMedSc(Hons)
Time commitment
Full-time
Top-up scholarship funding available
No
Physical location
Monash Medical Centre Clayton
Co-supervisors
Prof
Vincent Harley