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The role of branched chain amino acids and fatty acids in type 2 diabetes

Description 
The Metabolomics Laboratory uses state-of-the-art tandem mass spectrometry to obtain metabolic/lipid profiles from cell and animal models in addition to clinically relevant human samples to develop new approaches to diagnosis, risk assessment and therapy for diabetes and cardiovascular disease. We have recently identified that phospholipid species containing odd carbon and branched chain fatty acids show a strong negative association with obesity and type 2 diabetes. Previous studies have also identified a positive association between branched chain amino acids and type 2 diabetes. These fatty acid species are metabolically linked to the catabolic pathway of branched chain amino acids and a potentially causal pathway has recently been highlighted using Mendelian randomisation studies. However, we do not understand whether an increase in branched chain amino acids, a decrease in branched chain fatty acids or a combination of both contributes to the development of type 2 diabetes. We hypothesis that modulation of the branched chain catabolic pathway linking to the biosynthetic pathway of branched chain fatty acids will influence the onset of insulin resistance. This project is suitable for a PhD student and we will use cell culture and animal models to investigate the relationship between branched chain amino acids and branched chain fatty acids with insulin resistance, glucose tolerance and type 2 diabetes. This project has the potential to identify a new therapeutic strategy to prevent insulin resistance and progression to type 2 diabetes.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
lipid metabolism, type 2 diabetes, lipidomics, mass spectrometry,
School 
Baker Institute
Available options 
PhD/Doctorate
Masters by research
Honours
Time commitment 
Full-time
Top-up scholarship funding available 
Yes
Year 1: 
$6000
Year 2: 
$6000
Year 3: 
$6000
Physical location 
Baker Heart and Diabetes Institute, Commercial Rd, Prahran.
Co-supervisors 
Dr 
Kevin Huynh

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