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NMDA receptors, neural oscillations and cognition

Description 
NMDA receptors are brain ion channels involved in a range of cognitive functions. NMDA receptor antagonists block the opening of these channels, and cause disturbances to a range of cognitive processes, including working memory. In addition, NMDA receptor antagonists distort brain waves, especially high frequency brain waves, and this consequence may be critical to the effects on cognition. This project seeks to understand the mechanisms of how NMDA receptor antagonists create cognitive disturbance, with a focus on neural oscillations. Using a variety of genetically modified mice coupled with high fidelity in vivo electrophysiology and pharmacology, we will study oscillations during cognitive processing in the presence of NMDA receptor antagonists to attempt to identify the cellular mechanisms of action of these drugs.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
electrophysiology; cognition; animal model; transgenic manipulation; NMDA receptors, physiology, pharmacology, microbiology, anatomy, developmental biology, molecular biology, biochemistry, immunology, human pathology, clinical
School 
Central Clinical School » Neuroscience
Available options 
PhD/Doctorate
Masters by research
Masters by coursework
Honours
BMedSc(Hons)
Time commitment 
Full-time
Top-up scholarship funding available 
No
Physical location 
Alfred Research Alliance
Co-supervisors 
Dr 
Matt Hudson

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