NMDA receptors are brain ion channels involved in a range of cognitive functions. NMDA receptor antagonists block the opening of these channels, and cause disturbances to a range of cognitive processes, including working memory. In addition, NMDA receptor antagonists distort brain waves, especially high frequency brain waves, and this consequence may be critical to the effects on cognition. This project seeks to understand the mechanisms of how NMDA receptor antagonists create cognitive disturbance, with a focus on neural oscillations. Using a variety of genetically modified mice coupled with high fidelity in vivo electrophysiology and pharmacology, we will study oscillations during cognitive processing in the presence of NMDA receptor antagonists to attempt to identify the cellular mechanisms of action of these drugs.
electrophysiology; cognition; animal model; transgenic manipulation; NMDA receptors, physiology, pharmacology, microbiology, anatomy, developmental biology, molecular biology, biochemistry, immunology, human pathology, clinical
Central Clinical School » Neuroscience
Masters by research
Masters by coursework
Top-up scholarship funding available
Alfred Research Alliance