How do brain waves control cognitive processes? Using a combination of in vivo electrophysiology and sophisticated cognitive paradigms of working memory and attention, coupled with genetically modified mice, this project will record brain waves (local field potentials) and single unit activity during cognitive performance to attempt to answer this fundamental question. Several projects are ongoing. These include (1) deep characterisation of neuronal oscillatory patterns occurring during behaviour in different key brain regions; (2) manipulation of brain activity using optogenetic and chemogenetic technologies to infer causal consequences; (3) development of targeted pharmacotherapies to restore aberrant brain wave activity as potential treatment options for disorders with cognitive symptoms such as schizophrenia.
electrophysiology; cognition; animal model; transgenic manipulation; NMDA receptors, physiology, pharmacology, microbiology, anatomy, developmental biology, molecular biology, biochemistry, immunology, human pathology, clinical, neuroscience
Central Clinical School » Neuroscience
Masters by research
Masters by coursework
Top-up scholarship funding available
Alfred Research Alliance