Metaanalysis of prognostic tools for hypoxic ischemic encephalopathy

Accurate prediction of neurologic outcome after hypoxic coma is important. We have previously published on the utility of pupillary responses, sensory evoked potential (SEP) and EEG in predicting outcome after hypoxic coma in 2010 (Neurology, 2010;74:572–580). Our study demonstrated that sensory evoked potential (SEP) is marginally better than M1 at predicting outcome after hypoxic coma. However, the superiority of SEP diminishes after day 1 and when M3 is used. Since our publication, more diagnostic tools have been described.