You are here

Mechanisms of glucocorticoid action in disease

Description 
Diseases such as SLE (lupus) and rheumatoid arthritis (RA) are treated by glucocorticoids (steroids), because these drugs are highly effective. However, they have very significant side effects. We have made novel discoveries in the mechanisms of action of glucocorticoids, in order to unlock targets through which we can work towards a safe steroid mimic. This work is now at the stage of pushing towards a drug discovery program with interest from international partners, and student projects will have a major impact on advancing this program towards translation and commercialisation, providing therefore a learning experience that bridges science with translation.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
SLE, lupus, rheumatoid arthritis, RA, glucocorticoids, steroids, GILZ, MIF
Available options 
PhD/Doctorate
Masters by research
Honours
Time commitment 
Full-time
Top-up scholarship funding available 
No
Physical location 
Monash Health Translation Precinct (Monash Medical Centre)
Co-supervisors 
Dr 
Sarah Jones

Want to apply for this project? Submit an Expression of Interest by clicking on Contact the researcher.