Interventions for the prevention and treatment of metabolic and reproductive disorders

Overview of activities These studies examine the safety and efficacy of interventions (nutraceutical and pharmaceutical) for the prevention and treatment of diabetes (and its complications), gestational diabetes and adverse pregnancy outcomes. Major current projects include: - Metformin in Pregnancy Study (MiPS) – large collaborative project investigating the efficacy and safety of metformin in pregnancy to inform clinical guidelines - Hydoxychloroquine (HCQ) in pregnancy – collaborative project investigating the efficacy and safety of HCQ in pregnancy for the prevention / treatment of adverse pregnancy outcomes - Use of anti-depressant treatments (fluoxetine) during pregnancy: safety and effects on fetal outcomes - Effects of vitamin D on inflammation in type 2 diabetes, polycystic ovary syndrome and pregnancy And more.. These projects encompass a multidisciplinary approach with ample opportunities for students to obtain key research knowledge and skills. Multiple methodologies will be utilised to achieve the research aims, spanning across the research continuum from mechanistic and epidemiological research, to clinical trials, large-scale meta-analyses, and translational activities. Ideally, this work is suited for students with an interest in metabolism and reproducti health and with a passion for delivering research with impact. Given the timelines for most of these projects, Honours or Masters students may only be considered if they plan to progress to a PhD.