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Integration of population level ‘omics' data to target cardiometabolic disease

Description 
Cardiometabolic diseases represent the number one cause of death in the world, encompassing cardiovascular disease (CVD), type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), chronic kidney disease, and others. Dysregulation of lipid metabolism is intimately linked to the aetiology, progression, and sequelae of this collection of diseases. The Metabolomics Laboratory, at Baker Heart and Diabetes Institute, has developed a state-of-the-art lipid profiling methodology. Capable of measuring over 800 lipid species from less than a drop of blood, our lipid profiling has been used to improve the detection of people at risk of a large spectrum of conditions, including CVD, T2D, cancer, and Alzheimer’s disease. To further drive innovation in the field, we are integrating lipidomic and genomic data. Using novel statistical techniques, we aim to identify and evaluate the causal role of lipid metabolic pathways in cardiometabolic disease. With over 50,000 clinically relevant human samples already profiled, an exciting opportunity exists to identify new targets to prevent cardiometabolic diseases. This project is suitable for an Honours or PhD student and will focus on bioinformatic/statistical modelling with human clinical/population cohorts to investigate the relationship between lipid metabolism and cardiometabolic diseases.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
lipid metabolism, genetics, bioinformatics, lipidomics
Available options 
PhD/Doctorate
Masters by research
Honours
Time commitment 
Full-time
Top-up scholarship funding available 
Yes
Year 1: 
$6000
Year 2: 
$6000
Year 3: 
$6000
Physical location 
Baker Heart and Diabetes Institute, Commercial Rd, Prahran.
Co-supervisors 
Dr 
Corey Giles

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