Integrating living evidence into adaptive platform trials to create efficiencies in research generation

We are seeking expressions of interest from talented candidates who wish to apply for a PhD to undertake research enhancing adaptive platform trial (APT) design to improve efficiencies in research generation and accelerate the impact of research on health outcomes. The PhD research projects will be embedded in a wider research program funded by an NHMRC Ideas Grant focused on advancing adaptive platform trials by incorporating new external research as it emerges. The two PhD projects will be based at the Australian Living Evidence Collaboration within the School of Public Health and Preventive Medicine, and candidates will work closely with team members from multiple adaptive platform trials across Australia. This project aims to explore the processes for integrating living evidence into APT workflows and decisions, from the perspective of adaptive platform trial teams. This project would be ideally suited to a student who has experience working in clinical trials and may be a clinician, researcher, or student who is affiliated with an APT. The project will involve using an organisational readiness lens to understand and implement a co-designed living evidence method across two APT pilot sites. The student will also gain expertise in developing a scoping review and conducting and disseminating living evidence syntheses to inform APT decisions.