Project Overview: In the ever-evolving realm of immunology, the enigmatic world of non-canonical Human Leukocyte Antigen (HLA)-bound peptides beckons, promising revelations about the intricacies of immune function. Recent strides in bioinformatics and computational biology have ignited the path to uncovering the hidden secrets of these peptides, potentially revolutionizing our understanding of immune responses and propelling us toward groundbreaking therapeutic breakthroughs. Yet, the development of precise bioinformatic pipelines for their discovery remains a pivotal and thrilling challenge. Non-Canonical HLA-Bound Peptides: Beyond the boundaries of conventional peptides lies an uncharted territory of non-canonical HLA-bound peptides, holding the keys to unlocking a new dimension in immune interactions. These peptides defy traditional classification, inviting us to embark on a journey to unravel their mysteries and explore their potential in reshaping the landscape of immunology. The Role of Ribo-Seq Technology: In our quest to decode the immune enigma, we harness the power of Ribosome Profiling Sequencing (Ribo-Seq) technology. This cutting-edge method offers unprecedented insights into the translation of genetic information at a genome-wide scale, enabling us to comprehensively map the landscape of ribosome-protected mRNA fragments. By integrating Ribo-Seq data with bioinformatics approaches, we gain a deeper understanding of translational regulation within immune cells. This, in turn, aids in the identification of non-canonical HLA-bound peptides, shedding light on previously undiscovered facets of immune responses. Project Objectives: Pipeline Pioneering: Harness the cutting-edge potential of bioinformatics and computational tools, including Ribo-Seq techniques, to craft pioneering pipelines for the identification and characterization of non-canonical HLA-bound peptides. Illuminating Immune Complexity: Employ these pipelines, augmented by Ribo-Seq data, to shed light on the intricate world of non-canonical peptides, uncovering their roles in immune recognition, modulation, and response. Therapeutic Frontiers: Venture into the therapeutic potential of non-canonical peptides, with the goal of harnessing their unique attributes, identified through Ribo-Seq, to spearhead innovative immunotherapies. Project Benefits: Immunology Redefined: This project offers the chance to reshape our understanding of immune complexity, potentially unveiling novel avenues for therapeutic interventions. Bioinformatics Innovation: Contribute to the evolution of bioinformatics by forging pipelines tailored to the unique challenges posed by non-canonical HLA-bound peptides, supported by Ribo-Seq data. Therapeutic Exploration: Embark on a thrilling expedition into the uncharted realms of therapeutic potential, pioneering novel immunotherapies, guided by insights from Ribo-Seq. Project Requirements: Passion for Immunology: Seek individuals with an ardent passion for immunology and a deep-seated desire to decode the complexities of immune function. Bioinformatics Expertise: Ideal candidates should boast a robust background in bioinformatics and computational biology, with proficiency in Ribo-Seq analysis. Innovation and Dedication: Embrace creativity, innovation, and unwavering dedication to advancing the frontiers of immunology, bioinformatics, and Ribo-Seq techniques. How to Apply: Prospective candidates are urged to submit their applications, including a comprehensive CV and a cover letter outlining their qualifications, research experience, and an unwavering motivation to contribute to this transformative research endeavour. Together, we shall unveil the intricacies of immune function and pioneer new horizons in immunotherapy development, guided by the power of Ribo-Seq.
Non-canonical HLA-bound peptides, bioinformatic pipelines, immunology, bioinformatics, computational biology, immune function, therapeutic breakthroughs, immunotherapy development, immune complexity, innovative pipelines, immune response, bioinformatics innovation, precision immunology, immune modulation, immunotherapy research, immunological discoveries, immune interactions, therapeutic potential, scientific exploration, immunology redefined
Molecular and Translational Sciences
Masters by research
Top-up scholarship funding available
Monash Medical Centre Clayton