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Housekeeping transcriptional control: the TFIID master regulator

Description 
The eukaryotic genome consists of two classes of genes preceded by distinctly different promoter sequences. Housekeeping genes (90%) code for proteins that need to be produced at all times while stress genes (10%) code for proteins that are produced as responses to stress stimuli, such as starvation or infection. The PIC has a fundamentally different composition on these two classes of genes; 40% of the protein mass is unique in each complex because the one mega Dalton TFIID molecule exclusively regulates housekeeping genes. Most transcription research has focused on stress genes because the reaction is simpler to reconstitute. Biochemical and structural studies describing transcription initiation on housekeeping promoters are non-existent despite their fundamental importance to cellular biology.
Essential criteria: 
Minimum entry requirements can be found here: https://www.monash.edu/admissions/entry-requirements/minimum
Keywords 
transcription regulation, transcription factors, cancer, Department of Biochemistry & Molecular Biology
School 
Biomedicine Discovery Institute (School of Biomedical Sciences)Biochemistry and Molecular Biology
Available options 
PhD/Doctorate
Masters by Research
Honours
BMedSc(Hons)
Graduate Diploma
Short projects
Time commitment 
Full-time
Part-time
Top-up scholarship funding available 
No
Physical location 
15 Innovation Walk
Co-supervisors 
Assoc Prof 
Hans Elmlund

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